Medical marijuana news. Cannabidiol stops the spread of breast cancer.

[wildbilln864]

"We discovered that cannabidiol (CBD), a non-psychotropic compound from the plant Cannabis sativa, can inhibit the process of breast cancer cells that allow them to grow and spread (metastasis). CBD can also inhibit breast cancer metastasis in a mouse model. The research carried out in our CBCRP proposal demonstrated that CBD is a novel inhibitor of a gene whose activity is intimately linked to the aggressiveness of human breast cancers; this gene has been termed Id-1. Notably, our findings also indicated that Id-1 was a key gene whose expression needed to be reduced in order for CBD to inhibit aggressive breast cancer."

link to story

[Uncle Joe]

1. Kicked and recommended.

Thanks for the thread, wildbillin.:thumbsup:

[pleah]

2. K&R

:smoke:

[tridim]

3. Seems like Cannabis is the only drug with all positive side-effects.

Studies have also shown that it prevents neck and throat cancers.

[havocmom]

4. Until Big Pharma figures out a way to keep us from growing our own cures,

don't look for much help from pols to get this stuff available so we could have REAL Health Care Reform that actually made staying healthy more likely.

Think how much better earth would be if we gardened more than driving around to malls.

[crikkett]

21. Ha! I think this economy will force us to find out.

:hi:

[goclark]

38. My friend grew up in Arkansas

and she told me that whenever one of the children in the family got sick, the grandmother would send them to the back field for a certain tree berry.

If you had a cold, it would be the green berry tree.

If you had a bowel problem, it would be the red berry for example.

She never got sick for more than a day or two while she was growing up. The siblings had good health as well.

When she moved to CA and started taking Medicine, then she would have lingering colds etc.

In my case, my grandfather was an American Indian. When I would visit my grandparents in PA, I never took medicine.

If we coughed, we would try to hide from my grandfather. We knew that when he heard us cough this always happened....
Cough> grandfather would get one of his dirty socks and he would take his sock down stairs and we could smell him cooking onions
>he would come up stairs with the cooked fried onions in the dirty sock- I can still see him coming " I would beg him," Please granddaddy, not the sock,please!"

He did not listen of course and he would gently tie the sock around my neck, the smell was awful!

But, my cough went away almost instantly!

[truedelphi]

50. Hmmm, so here' s our choice I guess - dirty sock

Or huge big reefer!

I think you made me a marijuana convert!

[goclark]

51. Hope so ~ my Mom's boyfriend is on Medical MJ

and he is 91 years old.

Since he started on it he is doing at least 40 percent better.

Don't mind me because I am allergic to most MEDS. I drive the Dr's crazy and I stay afraid.

[truedelphi]

52. I have driven doctors crazy for years.

Currently I have one that refuses to go nuts over my stances, and he is patient and helpful. But it took me two years to find him.

I think I thank him (mentally) every other day of my life. What a goddess-send!

[pipoman]

12. A month ago there was a story about it inhibiting lung cancer too..

[wildbilln864]

22. Yes and...

Rick Simpson says it cured his cancer too.

Run from the Cure; The Rick Simpson Story

[suede1]

5. Hear hear! A big K&R!

[Uncle Joe]

6. Kicked for the night crew. n/t

[BlancheSplanchnik]

7. I don't get this circular statement....

"CBD is a novel inhibitor of a gene whose activity is intimately linked to the aggressiveness of human breast cancers; this gene has been termed Id-1. Notably, our findings also indicated that Id-1 was a key gene whose expression needed to be reduced in order for CBD to inhibit aggressive breast cancer"

Ok, this seems to say that CBD (cannabidiol) inhibits the gene (Id-1) which when active, increases or allows aggressive cancer cell growth. BUT, then it says, for CBD to inhibit aggressive growth, Id-1 must be inhibited......

that sounds like a pretty circular statement to me.......
if anyone can clarify, that'd be great

[Uncle Joe]

8. I'm not a doctor but I wonder if the key word is "novel"?

There is also this sentence later in the report.

"Building of the previous findings, we made small structural changes to CBD that are expected to produce drugs that are much more active than CBD at inhibiting Id-1 and corresponding aggressive breast cancers."

[BlancheSplanchnik]

62. hmmm..I don't know!

:shrug:

:)

"novel" might have a different medical definition than in regular old English..... I just don't know! :stumped:

Sorry to take forever to say thanks for the help....
running around busy--and off I go again now.............

:hi:
:sprint:

[nuxvomica]

23. I think they are saying...

"We noticed the CBD effect on metastasis and we know it inhibits Id-1 and we know that inhibiting Id-1 is necessary to inhibit metastasis." So they are laying out how they came to this conclusion. That's my reading of it but I'm no doctor or scientist.

[BlancheSplanchnik]

63. thanks for giving me a hand here

:)

I'll have to take a little more time to ponder this one.....if I had time....

which I don't!!!
:P


gotta run....

:hi:

[Soylent Brice]

9. neato

:thumbsup:

[donheld]

10. Cool beans

:bounce:

[RainDog]

11. knr

[pipoman]

13. For decades

there were few or no US studies done on cannabis. Now with the quasi legalization in CA, CO there are some actual scientific studies being done. There are several in the peer review stage right now...interesting times

[Fly by night]

14. Unfortunately, no studies of the medical uses of cannabis can occur in this country ...

... without prior federal approval (including approval from the National Institute on Drug Abuse, which admits it's mission is to study the hazards of cannabis, not its beneficial effects) AND without using cannabis (of dubious quality) provided by the government's pot farm at Ole Miss.

Even though California researchers have very high quality cannabis at their disposal (as do researchers in 13 other states and DC which have legalized med pot so far, with six more to follow before the end of the year), the recent report from the Center for Medical Cannabis Research at US-SD reviewed studies that were forced to use the Ole Miss schwag. Even using that inferior pot, the researchers found that cannabis unequivocally reduced neuropathic pain and spasticity in multiple sclerosis. Here's a link to that report: www.cmcr.ucsd.edu/CMCR_REPORT_FEB17.pdf

Serious and far-reaching research on medical cannabis in this country will require both reclassification of cannabis in the Controlled Substance Act and breaking the monopoly on research-grade pot at Ole Miss. Two separate DEA administrative law judges have recommended those changes, both of whom were overruled by the DEA director (including the one reappointed by AG Holder last month.)

[donquijoterocket]

40. all well and good

I'm foursquare for increasing our knowledge of the efficacy of medical marijuana, but nothing is going to stop the blue noses, reefer madness types, and committed drug warriors from trying to stop the medicalization of marijuana.Big pharma will be willing to bankroll just as big oil and energy are willing to bankroll climate change deniers. It'll be an uphill battle but I think eventually we'll see medical marijuana dispensaries alongside, if not inside Walgreen's, Walmart, and CVS pharmacies.

[pipoman]

60. I am not a pot smoker

and I am starting to believe that the substance deserves extensive testing. Further, we have now had 3 presidents in a row who have admitted to smoking pot, and countless legislators. Many seniors have, and some undoubtedly still do. The number of people (voters) who believe the reefer madness madness are becoming fewer and farther between. Medical use is happening now, the FDA, and other federal agencies just haven't quite gotten the memo from their bosses (the voters who have passed the med laws in those states which have them) yet that they had better abandon their bull headed approach to this substance, they will.

[AlecBGreen]

15. can someone please explain

why cannibas is still listed as a Class I "no-medicinal-value-whatsoever" drug? :crazy:

[bertman]

28. Reasons (not necessarily in order of importance): 1. Gives law enforcement another reason

to pry into Americans' private lives;

2. Gives the Prisons-for-Profit industry a steady supply of new customers for whom you and I must pay an arm and a leg to house and incarcerate;

3. Gives the "judicial system" another cash cow for bribes;

4. Gives the religious right another moral law to feel indignant about and demand retribution for;

5. Helps finance the purchase of more weaponry, high-tech surveillance equipment (including bugging equipment, helicopters, infra-red detection gear, etc.), through the sale of confiscated property (vehicles, homes, land, etc.);

6. Helps to finance the hiring and training of more fascist types who want to carry weapons and burst into peaceful citizens' homes and treat them like terrorists;

7. We simply cannot allow citizens to use a drug that makes them feel good without lots of negative side effects;

8. Provide a huge profit-making black market for anyone who wants to become involved in the illicit marijuana growing, importing, selling bidness.

9. Provide a solid market for black-market weapons used by the various gangs that control the lucrative marijuana importation, growing, selling bidness.

10. Eliminate a source of free medicine that would compete with Big Pharma's profits.

Just to name a few off the top of my head.

There's a great book that explains all of this in historical detail: "Drugs; America's Holy War" by Arthur Benavie.

[suede1]

34. Very good!

[lib2DaBone]

39. The U.S. locks up more citizens that any country in the world

[ooglymoogly]

47. I agree, we are living in a fascist state

Afghanistan and the gulf oil governments, however are not a fair comparison. They just shoot or decapitate anyone who disagrees with them, case closed; No prisons, as in most loony religious states, are needed. Wait until they catch on how much can be made off state owned slaves. Here of course we have corporate prisons of legal slavery; Thares gold in them thar slaves owned by the state.

[Guilded Lilly]

46. That's EXCELLENT for just off the top of your head (grin)

I would have just posted *Government makes more $ from it being illegal*
Your list is wonderful!
Thanks :)

[bertman]

59. Thanks, Lilly. I have done a good bit of research and reading on this over the last year

or so. I have a friend who got busted for possession of a few plants (two or three). The corruption involved in getting the felony "crime" turned into a misdemeanor was an eye opener for me.

It's nothing more than a racket. We're talking about the law enforcement officials and the so-called justice system, including lawyers and prosecutors.

My friend had never been convicted of anything in her life. Works her ass off. Honest as the day is long. And a Repuke to boot. Get this, she had to pay a "fine" of $10,000 to the cops and was told she couldn't tell anybody about having to pay the "fine". Plus, she's still going through court proceedings to get the charges reduced.

I used to believe in our criminal justice system.

[wildbilln864]

66. Oh man...

she should have documented that $10,000.00 bribe IMHO.

[bertman]

67. That was her call. I was not sought out for advice and I was not involved. It makes me

almost physically ill to think about it and how much harm has been done to her in many ways.

It's gonna be really hard to get legislation to legalize pot when the people with the power and the guns are making so much money off it being illegal.

[wildbilln864]

68. Even impossible for a while I think....

It's more profitable to treat ailments for entire lifetimes than to cure someone. Once they're cured, the money stops coming from those people. Can't have that. :banghead:

[BakedAtAMileHigh]

16. and brain tumors. and lung tumors. Cannabis is Incredible Medicine.

If people bother doing a little bit of research it is amazing what you can find.

Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/105/3/1214

Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
http://www.jci.org/articles/view/16116/version/1

Cannabis extract makes brain tumors shrink, halts growth of blood vessels
http://www.medicalnewstoday.com/articles/12088.php

"Make your food your medicine and your medicine your food." -- Hippocrates

[whistler162]

17. Don't forget it stops fallen arches and nose hair!

[BakedAtAMileHigh]

18. why don't you read the studies first, genius

Because there is very real science to all of this.

I want to be clear about this: I work with scientific researchers and medical professionals who specialize in the use of cannabis and cannabinoid therapies for cancer and HIV patients as well as people who suffer from MS and various forms of epilepsy. I know this emerging science quite well and I am fully comfortable calling you a fool for your response.

I'm sick and tired of ignorant idiots who have been fully propagandized supporting a system and understanding of the world that leads to the criminalization of patients and the suppression of effective, natural medicine in favor of deadly pharmaceuticals.

Some people are starting to catch on: the current number of Colorado MMJ patients is growing by hundreds every day. You seem to have some catching up to do.

[ChiciB1]

19. Good Reply! And Aren't there Actually Doctors In CA Who Are Now

calling themselves endocanabinoid doctors. Or perhaps I have the terminology wrong. Seems I read an article about these doctors, but I may have the description wrong. Anyway, doctors who "specialize" in this field and are part of a growing new medical field.

I'm sure that someone here knows what I'm talking about better than I. I say, IF this is a plus, as we have come to realize that stem cell research has been, then we as a NATION had better wake up. Other nations have passed us on many other levels, so I'm not sure I hold out much faith about what they might want to do, given the legal Prohibition in this country!

JMHO!

[ChiciB1]

20. Whoops, That Was A Question... Not A Statement... Forgot My "?" Mark!

Again, I like your thinking and those who want to make "wise cracks" about this don't really seem to understand the REAL concept behind the medicinal use here!

I myself have no need for the weed even though I was once a user for "fun!" As time has gone by I use only on a VERY limited basis even though I still know people who are daily users... for fun or relaxation.

I just don't like having the "munchies" because of my overwhelming fear of gaining weight! If it weren't for this fact, I would still be toking! For those who can do it and not delve into any food item that crosses their nose, more power to them! I was NEVER able to do that... any food I saw went into my mouth, and for some reason... it just wasn't exactly what I wanted, so I moved onto another food group! Then when it wore off I sat there bloated and mad that I was unable to control my inability to STOP eating.

I've laughed many times in the past thinking I would have eaten "wood" if it had mustard on it!! Now, I'm making fun!

Still, knowing that this is still classified as a Class I narcotic, it blows my mind! METH, CRANK, HEROIN, hey give me a BREAK!!

[Fiendish Thingy]

25. as someone involved in cannabis research, wouldn't you agree...

that, just as with any other medication or medical treatment, cannabis-based treatments should undergo the same rigorous peer reviews to verify methodology and statistically significant results before pronouncing it as definitively effective in treating a particular condition or ailment? If I had cancer, I'd want a treatment with the strongest scientifically proven success rate.

Unfortunately, propaganda can cut both ways.

IMO, that is one of the biggest justifications for legalization/decriminalization- remove cannabis from Schedule I so it can be appropriately researched in controlled conditions, with that research widely published, reviewed, and most importantly, replicated to strengthen any scientifically sound results.

Other alternative medicine methods have science to back some, but not all, of their therapeutic claims- acupuncture, chiropractic, homeopathic, etc.

In addition, solid, unrestricted research would also provide scientific, unbiased information on the harmful effects of cannabis use, without having to rely on scare tactics and anectodal evidence.

[BakedAtAMileHigh]

61. oh for chrissakes

I am constantly amazed at how much ignorance there is on this subject in the US.

There is absolutely nothing "new" or unproven about the information; the US government knew in 1974 that THC and other cannabinoids kill tumors: it was proven in a study at the University of Virginia that was subsequently shut down by the federal government. There is real, actual verified science available on all of this if people bother to get off their lazy asses, turn off the televisions and look for it. There is no research done in the US but much has been done and continues across the world, particularly Spain and Israel.

The anti-tumor properties of THC and endogenous cannabinoids has been well-documented; peer reviewed studies have even appeared in "Nature" and many other medical journals. Does the US desperately need to stop the war on a plant? Of course. But there is already much documented research on the topic, don't be fooled.

[ooglymoogly]

48. No it does not do that, however it does

expose idiots for what they are.

[wildbilln864]

24. and there's this...

page about some studies done. :hi:

[bjjblackbelt]

26. ...

I wonder how long ago the govt knew about this and other benefits from cannabis?

[wildbilln864]

53. they've know since '74...

that it stopped cancer.

[bjjblackbelt]

56. ...

My grandmother died of breast cancer when i was one years old. I am the only grandson she ever knew as Im the eldest among my cousins. I'm told she would try to carry me with one arm after she had to have her breast and the other one amputated. She died in '79. The criminals are still out there, in power and still influencing policy. There is no justice.

[wildbilln864]

65. So sorry for your loss.

It took a long time to get past loosing my Granny. She practically raised us.
You're right though there is no justice for the poor and middle class.
Welcome to the DU BTW too. :hi:

[proudohioan]

27. Always good news to hear about anything that stops the spread of caner!

[asdjrocky]

29. Hemp can save the world.

Cannabis can save our bodies and our heads.

[unapatriciated]

33. and the economy.

:hi: I do not state that in jest. Hemp has many uses yet it is still illegal to grow in most states.
http://environment.about.com/od/greenlivingdesign/a/hemp.htm

[unapatriciated]

30. Thanks for posting this. They have had this info for some time yet chose to ignore it.

http://www.democraticunderground.com/discuss/duboard.php?az=show_mesg&forum=102&topic_id=3812502&mesg_id=3812725

[Clear Blue Sky]

31. Great if you are a mouse. Don't know if it has the same effect in humans.

[Cerridwen]

35. Kinda like all the drug research done using mice, huh.

[Greyhound]

37. The breast cancer genes these mice carry is human, that's why the little buggers cost

so much. While far from conclusive, this is very significant.

[Enthusiast]

32. Not that there is a correlation

but my lifelong friend is dying from cancer. He was a huge marijuana smoker. Huge!

[Name removed]

41. Deleted message

Message removed by moderator. Click here to review the message board rules.

[Codeine]

42. Posting snake-oil woowoo shit like that

shouldn't be tolerated.

[Aaria]

43. Didn't read any of it did you.

[Aaria]

57. I know that implying that a food could cure cancer is too far out there

for some people to grasp, but you should let the recipient of the post decide. Maybe he would like to know that there is another choice out there that has worked for others, like Don Imus with his prostate cancer. If you had read the article and some of the forum post you would have found out that there are people using the recipe called out in the article and you would have learned that it does work. But we need another person on chemo with it's 3% success rate and big medicine sucking the like and every dime out of them, with no other choice. We're all one big family, helping each other is all we got, if it worked for Imus then why not someone else.
Flame on.

[Codeine]

58. Thankfully the mods agreed with me. nt

[Aaria]

64. Nice.

[wildbilln864]

54. Well according to Ricky Simpson...

you have to ingest the oils and compounds in large concentrated quantities for it to be effective.

[Joey Liberal]

36. Good info. nt

[SlingBlade]

44. K & R

[Rozlee]

45. Someone told me this about LSD; don't know if it's true. Supposedly some

tests showed that it or some compound of it caused marked and immediate improvement in symptoms of schizophrenia. But, that blanket laws against all psycotropic drugs by conservatives in the 70s, even for experimental lab use, put the kibosh on research for it. Does anyone know anything about this? Because if this is true, they are true bastards. (Not that we didn't know this already).

[rcrush]

49. I've been told that Psilocybin (shrooms) stops migraines dead on.

I don't think I get what are normally called Migraines but I do get regular headaches and whenever I tripped they went away.

[wildbilln864]

55. here's more evidence...

of studies done on MJ. :hi: