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toxins are applying to the human condition. While I realize the journal Reproductive Medicine may not be all that, I feel that there must be at least a little truth to this. 1: J Reprod Med. 2002 Oct;47(10):821-4. Improvement in sperm quality and function with French maritime pine tree bark extract. * Roseff SJ. West Essex Center for Advanced Reproductive Endocrinology, 741 Northfield Avenue, Suite 100, West Orange, NJ 07052, USA. sroseff@reproendo.com OBJECTIVE: To determine the effects of Pycnogenol (French maritime pine tree bark extract) on sperm parameters and function in subfertile men. STUDY DESIGN: Prospective, nonrandomized, clinical study in a private infertility practice. Nineteen subfertile men were given 200 mg Pycnogenol daily orally for 90 days. Semen samples were analyzed before and after treatment for sperm count, motility score and strict morphology before and after capacitation, and mannose receptor binding. RESULTS: The mean sperm morphology following Ham's F-10 capacitation increased by 38% following Pycnogenol treatment, and the mannose receptor binding assay scores improved by 19%. CONCLUSION: Pycnogenol therapy resulted in improved capacitated sperm morphology and mannose receptor binding. The increase in morphologically and functionally normal sperm may allow couples diagnosed with teratozoospermia to forgo in vitro fertilization and either experience improved natural fertility or undergo less invasive and less expensive fertility-promoting procedures, such as intrauterine insemination. PMID: 12418064
1: J Med Food. 2006 Fall;9(3):440-2.Click here to read Links Improvement in human semen quality after oral supplementation of vitamin C.
* Akmal M, * Qadri JQ, * Al-Waili NS, * Thangal S, * Haq A, * Saloom KY.
Dubai Specialized Medical Center & Research Labs, Dubai.
This study was carried out to monitor the effect of oral supplementation of vitamin C on various semen parameters in oligospermic, infertile, otherwise healthy individuals. Various semen parameters, including sperm motility, sperm count, and sperm morphology, were studied before and after the vitamin C treatment. A total of 13 infertile patients were included. Their ages ranged between 25 and 35 years. They had no genital infection or varicocele. Physical examination and other routine laboratory investigations were normal. General semen analysis revealed oligozoospermia (mean sperm count was 14.3 +/- 7.38 x 10(6) sperms/mL, mean sperm with normal morphology was 43 +/- 7.87%, and mean sperm motility was 31.2 +/- 9.61%). Testicular biopsy was not done. These patients received in an open trial of 1,000 mg of vitamin C twice daily for a maximum of 2 months. Results showed that the mean sperm count was increased to 32.8 +/- 10.3 x 10(6) sperms/mL (P < .001) after 2 months of vitamin C intake. The mean sperm motility was increased significantly to 60.1 +/- 8.47% (P < .001), and mean sperms with normal morphology increased significantly to 66.7 +/- 4.77% (P < .001). This study showed that vitamin C supplementation in infertile men might improve sperm count, sperm motility, and sperm morphology and might have a place as an additional supplement to improve the semen quality towards conception.
1: Metabolism. 2003 Apr;52(4):402-6.Click here to read Links Coenzyme Q10: another biochemical alteration linked to infertility in varicocele patients?
* Mancini A, * Milardi D, * Conte G, * Bianchi A, * Balercia G, * De Marinis L, * Littarru GP.
Institute of Endocrinology, Catholic University of the Sacred Heart, Rome, Italy.
Previously we demonstrated that coenzyme Q10 (CoQ10) is present in human seminal fluid and shows a direct correlation with seminal parameters except in patients with varicocele (VAR). We have now evaluated CoQ10 distribution in VAR, versus control subjects, in order to discover metabolic abnormalities within this condition. We studied 32 patients with VAR (11 with oligoasthenozoospermia, 13 with asthenozoospermia, and 8 with normozoospermia), and, as controls, the following groups of subjects, matched with VAR patients according to seminal parameters: 16 patients with idiopathic oligozoospermia, 11 patients with isolated asthenozoospermia, and 14 normal fertile men. CoQ10 was assayed in total seminal fluid, plasma, or cell pellet by high-performance liquid chromatography (HPLC). We found a significantly higher proportion of CoQ10 in seminal plasma in VAR; cellular CoQ10 showed an inverse correlation with sperm concentration and motility in VAR, at variance with controls. As seminal plasma ubiquinone reflects an interchange between intracellular and extracellular compartments, the different distribution in VAR patients could represent a greater sensitivity to peroxidative damage and could suggest reduced utilization for energy, which in turn could cause a defective motility even in patients with a normal cell count. These data suggest a pathophysiological role of CoQ10 in seminal plasma and a possible molecular defect in VAR. Copyright 2003 Elsevier, Inc. All rights reserved.
PMID: 12701049
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