Fat-producing gene may be clue to obesity

[rpannier]

Lab study offers new clues about how the body metabolizes carbohydrates

CHICAGO - U.S. researchers have found a gene responsible for turning a plate of pasta into fat, offering new clues about how the body metabolizes carbohydrates and how they contribute to obesity.

The gene, called DNA-PK, appears to regulate the process in the liver that turns carbohydrates into fat, the University of California, Berkeley team reported on Thursday in the journal Cell.


snip

"The DNA-PK disabled mice were leaner and had 40 percent less body fat compared with a control group of normal mice because of their deficiency in turning carbs into fat," Wong said.

snip

Since humans have the same gene, the team thinks it may serve as a potential target for drugs to prevent obesity.

link:
http://www.msnbc.msn.com/id/29790543/

[barbtries]

1. i'll be first in line

to have my DNA-PK disabled, if it means i can still be healthy while i get a handle on this fat.

[HysteryDiagnosis]

2. May I suggest you read up on this recent news regarding

a common supplement??

http://www.nature.com/nature/journal/v444/n7117/abs/nature05354.html

Resveratrol (3,5,4'-trihydroxystilbene) extends the lifespan of diverse species including Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster. In these organisms, lifespan extension is dependent on Sir2, a conserved deacetylase proposed to underlie the beneficial effects of caloric restriction. Here we show that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival.

Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) activity, increased mitochondrial number, and improved motor function.

Parametric analysis of gene set enrichment revealed that resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways. These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing.

[rpannier]

3. Thanks for posting

I had never heard of it

Although, I don't have a weight problem, it is always a good thing to get information out to people.

Thanks

[HysteryDiagnosis]

4. But wait.... there's more!!! and you are most welcome.

http://cat.inist.fr/?aModele=afficheN&cpsidt=18598418


Résumé / Abstract
Whether resveratrol, a component of red grapes, berries, and peanuts, could suppress the proliferation of multiple myeloma (MM) cells by interfering with NF-κB and STAT3 pathways, was investigated. Resveratrol inhibited the proliferation of human multiple myeloma cell lines regardless of whether they were sensitive or resistant to the conventional chemotherapy agents. This stilbene also potentiated the apoptotic effects of bortezomib and thalidomide. Resveratrol induced apoptosis as indicated by accumulation of sub-G1 population, increase in Bax release, and activation of caspase-3. This correlated with down-regulation of various proliferative and antiapoptotic gene products, including cyclin D1, clAP-2, XIAP, survivin, Bcl-2, Bcl-xL, Bfl-1/A-1, and TRAF2.

In addition, resveratrol down-regulated the constitutive activation of AKT. These effects of resveratrol are mediated through suppression of constitutively active NF-KB through inhibition of IκBα kinase and the phosphorylation of IκBα and of p65. Resveratrol inhibited both the constitutive and the interleukin 6-induced activation of STAT3. When we examined CD138+ plasma cells from patients with MM, resveratrol inhibited constitutive activation of both NF-κB and STAT3, leading to down-regulation of cell proliferation and potentiation of apoptosis induced by bortezomib and thalidomide.

These mechanistic findings suggest that resveratrol may have a potential in the treatment of multiple myeloma.

[barbtries]

5. thanks

have to pay to read it, unless we have that issue at work, we might. i've never heard of Resveratrol - is it marketed already?

[HysteryDiagnosis]

6. It is derived from either grape seeds or perhaps pycnogenol... I

want to say red wine is involved or that there is "some" resveratrol in red wine. I am going to do something I never do, I will link you to an article to some very bad people who not only teach you about supplements and drugs, they also promote them for profit. Please know that I have absolutely NOTHING to do with this highly valued IMHO.


http://search.lef.org/search/default.aspx?s=1&QUERY=resveratrol

PLEASE just read the FREE articles and then afterwards let your conscience be your guide, personally, I shop for most of my snake oil at the vitaminshoppe.