Tuberculosis in Africa — Combating an HIV-Driven CrisisRichard E. Chaisson, M.D., and Neil A. Martinson, M.B., B.Ch., M.P.H.Africa is facing the worst tuberculosis epidemic since the advent of the antibiotic era. Driven by a generalized human immunodeficiency virus (HIV) epidemic and compounded by weak health care systems, inadequate laboratories, and conditions that promote transmission of infection, this devastating situation has steadily worsened, exacerbated by the emergence of drug-resistant strains of tuberculosis.
Africa, home to 11% of the world's population, carries 29% of the global burden of tuberculosis cases and 34% of related deaths, and the challenges of controlling the disease in the region have never been greater. The World Health Organization (WHO) estimates that the average incidence of tuberculosis in African countries more than doubled between 1990 and 2005, from 149 to 343 per 100,000 population (see maps)1 — a stark contrast to the stable or declining rates in all other regions during this period. In 1990, two African countries, Mali and Togo, had an incidence greater than 300 per 100,000; by 2005, 25 countries had reached that level, and 8 of them had an incidence at least twice that high.
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As HIV prevalence increased in Africa — most strikingly in the 1990s — and the cellular immunocompetence of populations became impaired, susceptibility to tuberculosis grew dramatically. South African gold miners, for example, already had one of the highest incidence rates of tuberculosis in the world, but rates remained stable between 1990 and 1999 among HIV-negative miners, while rates among HIV-positive miners increased by a factor of 10.
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In the midst of this bleak situation, there is a glimmer of hope. In 2005, the African ministers of health declared a "TB Emergency," promising swift and concerted action to combat the disease. And the global health community has increased its investment in tuberculosis control and research. HIV activists, having achieved success in their AIDS awareness and funding efforts, have set their sights on tuberculosis. At an international tuberculosis conference in South Africa in November 2007, more than 3000 delegates brought a new level of attention and urgency to Africa's unprecedented health problems.
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