Major Depression and Coenzyme Q10 Levels... contraindication

[HysteryDiagnosis]

for statins....

Neuro Endocrinol Lett. 2009;30(4):462-9.
Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness.

Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E.

Maes Clinics, Antwerp, Belgium. [e-mail]

INTRODUCTION: There is now evidence that major depression is accompanied by an induction of inflammatory and oxidative and nitrosative stress (IO&NS) pathways and by a lowered antioxidant status. Coenzyme Q10 (CoQ10) is a strong antioxidant that has anti-inflammatory effects. METHODS: This paper examines the plasma concentrations of CoQ10 in 35 depressed patients and 22 normal volunteers and the relationships between plasma CoQ10 and treatment resistant depression (TRD), the severity of illness as measured by means of the Hamilton Depression Rating Scale (HDRS) and the presence of chronic fatigue syndrome (CFS).

RESULTS: We found that plasma CoQ10 was significantly (p=0.0002) lower in depressed patients than in normal controls. 51.4% of the depressed patients had plasma CoQ10 values that were lower than the lowest plasma CoQ10 value detected in the controls. Plasma CoQ10 was significantly lower in patients with TRD and with CFS than in the other depressed patients. There were no significant correlations between plasma CoQ10 and the HDRS.

DISCUSSION: The results show that lower CoQ10 plays a role in the pathophysiology of depression and in particular in TRD and CFS accompanying depression. It is suggested that depressed patients may benefit from CoQ10 supplementation. The findings that lower CoQ10 is a risk factor to coronary artery disease and chronic heart failure (CHF) and mortality due to CHF suggest that low CoQ10 is another factor explaining the risk to cardiovascular disorder in depression. Since statins significantly lower plasma CoQ10, depressed patients and in particular those with TRD and CFS represent populations at risk to statin treatment.

PMID: 20010493

[UndertheOcean]

1. Rec !

[HysteryDiagnosis]

2. Continuing with the theme.... there are molecules in the human

body that have such a huge job, such a protective role to play... coenzyme q10 is but one of them. Going around with too little of it, either due to genetics, environment or medication is no way to live. People who publish papers stating that supplements do little if any good for anyone are pretty much full of bat guano. Who knew that oxidative stress could be a player in CAD and depression? Who knew that you could do more than just play around with neurotransmitter receptors?? Who knew that the human body/mind could be healed/protected rather than just bandaided. (my deliberate mispell}



J Affect Disord. 2010 Jan 16.
Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: Markers that further explain the higher incidence of neurodegeneration and coronary artery disease.

Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E.

Maes Clinics, Belgium.

BACKGROUND: Major depression is characterized by a decreased antioxidant status, an induction of the inflammatory and oxidative and nitrosative (IO&NS) pathways and inflammatory-neurodegenerative (I&ND) pathways. This study examines two markers of oxidative stress in depression, i.e. plasma peroxides and serum oxidized LDL (oxLDL) antibodies.

METHODS: Blood was sampled in 54 patients with major depression (mean+/-SD age=43.5+/-11.6years) and 37 normal volunteers (43.6+/-11.1years). The severity of illness was measured by means of the Hamilton Depression Rating Scale. The Fibromyalgia and Chronic Fatigue Syndrome Rating Scale was used to measure severity of "psychosomatic" symptoms in depression.

RESULTS: We found significantly higher plasma peroxides (p=0.002) and serum oxLDL antibodies (p=0.0002) in depressed patients as compared to normal controls. There was no significant correlation between both markers and both independently from each other predicted major depression. There were significant correlations between the oxLDL antibodies and the scores on two items of the FF scale, i.e. gastro-intestinal symptoms and headache.

DISCUSSION: The results show that major depression is accompanied by increased oxidative stress and lipid peroxidation. These results further extend the IO&NS pathophysiology of major depression. Since increased peroxides and oxLDL antibodies are predictors of coronary artery disease (CAD) and neurodegeneration, our findings suggest that IO&NS pathways are involved in the increased incidence of both CAD and neurodegeneration in depression. Copyright © 2009. Published by Elsevier B.V.

PMID: 20083310

[emilyg]

3. k

[KT2000]

4. Have you read the work

of Martin Pall, PhD?
He is working on a theory of oxidative stress and the nitric oxide cycle. You might find it interesting. He has come up with a list of supplements that down regulate the NO cycle.


http://thetenthparadigm.org/index.html

[HysteryDiagnosis]

5. This idea will immediately fall into the realm of quackery but then

that is how it has always been.