Magnesium and sleep

[HysteryDiagnosis]

http://www.highbeam.com/library/docfree.asp?DOCID=1G1:114820669&ctrlInfo=Round19%3AMode19a%3ADocG%3AResult&ao=

Magnesium

The most abundant positively charged electrolyte in the body, magnesium is necessary for the movement of ions across cellular membranes and the transmission of nervous impulses. (7) The role of magnesium in the nervous system has led to its intense study throughout the medical literature. Known for its ability to affect sleep, sleep-related neuroendocrine functions, and EEG (electroencephalogram) patterns, magnesium was utilized as a treatment for insomnia in the elderly in one study. (8) The authors of this study noted that decreases in several sleep measurement indices (decreased slow wave sleep and delta and sigma wavelength power) were improved upon supplementation of magnesium. These investigators suggest that magnesium, used as a sleep aid, may affect glutaminergic and GABAnergic neurotransmitter systems and can alter age-related sleep changes.

Subsequent depletion of magnesium associated with low intake is thought to disrupt normal biologic rhythms including sleep cycles. Low intake is associated with hypo- and hyperfunction of the biologic clock; hyperfunction of the biologic clock is associated with various manifestations of nervous hypoexcitability such as depression, headaches, and myalgias (fibromyalgia, chronic fatigue syndrome) while hypofunction is associated with expression of nervous hyperexcitabity such as delayed sleep onset, age-related insomnia, anxiety, and migraine. (9) Researchers speculate that the role of the biologic clock and magnesium are linked in a way that a certain level of magnesium is necessary for the efficient function of the pineal gland and the suprachiasmatic nuclei. (10) Additionally, this research hypothesizes that magnesium may stimulate inhibitory neurotransmitter systems such as GABA and taurine and may antagonize carbon monoxide and nitric oxide, gases characterized as "neuroactive." Clinically, the authors of this paper note a beneficial effect of magnesium supplementation in the late evening hours on sleep quality; this effect is achieved with 200-300 milligrams over a period of one to two weeks of continuous supplementation. Magnesium plays an interesting role in the function of biologic rhythms; more research is needed in this area.

[Jane Austin]

1. Thanks for posting that.

I had just read that one needs magnesium in order for calcium supplementation to be effective.

I have some of the problems mentioned -- especially since 12-12-2000.

[HysteryDiagnosis]

2. Please follow the link and know that 5-Hydroxytryptophan and the

other items are certainly worth reading about. Also know that I am a middle aged male and I take Cal/Mag everyday. the vitaminshoppe.com has some of the best prices online if you are so inclined, they have an 800# if online purchasing is not your cup of tea.

[petersjo02]

3. Thanks for posting

I sleep well once I get to sleep but have a very hard time shutting my mind off so that I can get to sleep in the first place. I'm going to try this supplement.

[HysteryDiagnosis]

4. Some other interesting articles that some parents may be interested

in reading.....

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15466962&query_hl=1&itool=pubmed_docsum
CONCLUSION: This open study indicates that hyperexcitable children have low ERC-Mg with normal serum Mg(2+) values, and that Mg(2+)/vitamin B6 supplementation can restore normal ERC-Mg levels and improve their abnormal behavior.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9368236&query_hl=1&itool=pubmed_docsum
Hyperactivity was assessed with the aid of psychometric scales: the Conners Rating Scale for Parents and Teachers, Wender's Scale of Behavior and the Quotient of Development to Freedom from Distractibility. In the group of children given 6 months of magnesium supplementation, independently of other mental disorders coexisting with hyperactivity, an increase in magnesium contents in hair and a significant decrease of hyperactivity of those examined has been achieved, compared to their clinical state before supplementation and compared to the control group which had not been treated with magnesium.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16548369&query_hl=1&itool=pubmed_docsum
We studied prevalence of attention deficit hyperactivity disorder (ADHD) in senior schoolchildren of Nefteyugansk (Khanty-Mansysky autonomic region) it was 8% (13% among boys and 3% among girls). Clinical examination of 122 children, aged 6-11 years, revealed that risk factors for ADHD were perinatal CNS injures, familial predisposition, unfavorable social and psychological influences. Neuropsychological, neurophysiologic (electroencephalography) and biochemical study showed mild neurological disturbances, some peculiarities of motor and emotional spheres and higher mental functions. Moreover, there were such biochemical alterations as a decrease of magnesium level in the plasma and erythrocytes and a reduction of Mg(2+)-ATPase activity. The use of MAGNE-B6 allowed us to correct many of the disturbances.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16579066&query_hl=1&itool=pubmed_docsum

Nogovitsina OR, Levitina EV.

MAGNE-B6 was used for the therapy of a group of 31 children aged from 6 to 12 with attention deficiency and hyperactivity syndrome. The control group included 20 children with similar manifestations of the same pathology, which received a polyvitamin complex. The efficacy of therapy was assessed in the 30th day with the aid of a complex clinical-neuropsychological and biochemical investigations. It was established that the administration of MAGNE-B6 led to improvements in the behavior, decreased the level of anxiety and aggression, improved both large- and small-scale mobility, decreased the level of synkinesis, increased the characteristics of attention, corrected the magnesium homeostasis, and favored normalization of the blood electrolytes. Reliable differences (p < 0.01 or 0.001) between the test and control groups in the degree of expression of the indicated disorders were observed.

[BrklynLiberal]

5. Thank you very much for posting this...

:thumbsup: :hi: