Phase III trial recruiting, beneficial effects of CoQ10 for early

[HysteryDiagnosis]

Parkinson's disease.

http://www.clinicaltrials.gov/ct2/show/NCT00740714?term=parkinson%27s+coenzyme+q10&rank=1

Detailed Description:

Parkinson disease (PD) is a progressive neurodegenerative disease that affects more than 1,000,000 Americans.

Currently there is no proven therapy to reduce the rate of progression of PD. In a previous phase II clinical trial, investigators demonstrated that Coenzyme Q10 (CoQ) at dosages of 300, 600, and 1200 mg/day was safe and well-tolerated in individuals with early, untreated PD. The findings also suggested that CoQ may slow the progressive impairment of PD as measured by the Unified Parkinson Disease Rating Scale (UPDRS).

In this study, researchers will conduct a randomized, placebo-controlled, phase III trial of CoQ to confirm and extend the results of the earlier phase II study. The primary objective of this trial is to compare the effect of two dosages of CoQ (1200 and 2400 mg/day) and placebo on the total UPDRS score in people with early PD. The study also will evaluate independent function, cognition, and quality of life. Plasma CoQ levels will be measured at months 1, 8 and 16 and correlated with changes in UPDRS scores.

Participants will be randomly assigned to receive a placebo (an inactive substance), 1200 mg/d CoQ, or 2400 mg/d CoQ. They will be evaluated at screening, baseline, and during visits at months 1, 4, 8, 12, and 16.

Information gained from this trial could lead to changes in management of people with early PD.

[AwakeAtLast]

1. Kick in memory of my grandfather who suffered for more than 15 years

Let's hope they find the cure!

:kick: & R!

[wuvuj]

2. More info...

http://www.lef.org/LEFCMS/aspx/PrintVersionMagic.aspx?CmsID=111809


http://www.lef.org/LEFCMS/aspx/PrintVersionMagic.aspx?CmsID=115154


ubiquinol can be found fairly easily...more effective than regular COQ10...

[HysteryDiagnosis]

3. I hate to mention it but wallyworld has a form called Qunol... it

is supposed to be 3x more absorbable making 100mg equivalent to taking 300.

[laughingliberal]

4. Puritan's Pride also carries this supplement

called Ubiquinol. It is a more biologically active form of CoQ10.

[HysteryDiagnosis]

5. It's simply amazing how fiercely the pharmcos have fought to

make the benefits of key supplements virtually unknown as well as making it illegal to treat disease with them. If you have the time, may I recommend this video from the recently diceased Dr. Abram Hoffer... it should be a blessing for anyone dealing with mental health issues, their own of those of a family member/friend.


http://www.youtube.com/watch?v=dMMzS6tLnOE&feature=related

[grasswire]

6. I've noticed a marked difference in my health since starting coQ10

...and it's been about two years now. I take it for the cardio benefits.

And my dear kitty has just been started on it, too. 20 mg qod, for his hypertrophic cardiomyopathy.

[HysteryDiagnosis]

7. For those who don't get the gist of what you are saying...

http://www.amazon.com/Coenzyme-Phenomenon-Stephen-M-D-Sinatra/dp/0879839570/ref=sr_1_21?ie=UTF8&s=books&qid=1254099642&sr=8-21
http://ecx.images-amazon.com/images/I/51I8pZDzugL._BO2,204,203,200_PIsitb-sticker-arrow-click,TopRight,35,-76_AA240_SH20_OU01_.jpg


23 of 27 people found the following review helpful:
5.0 out of 5 stars The Coenzyme Q10 Phenomenon, April 20, 2000
By A Customer
Dr. Stephen Sinatra presents his material in an easy to understand format. He is writing for the professional as well as the layman interested in this subject. I highly recommend this book for anyone who is seeking information on heart disease, diabetes, peridontal disease or other degenerative diseases.

This books has lots of usefull inforCoenzyme Q10 (often abbreviated as CoQ10) is essential for human life. It catalyzes the formation and utilization of energy in every human cell. Fortunately, our bodies manufacture CoQ10. Unfortunately, some people do not manufacture enough CoQ10 to keep them healthy, especially as they grow older. Research has shown that deficiency of CoQ10 is the major cause of cardiomyopathy, and congestive heart failure and these diseases can often be cured by CoQ10 supplementation.

Even many heart transplant candidates have no longer needed a heart transplant after supplementation with CoQ10. Now it has been found that CoQ10 can also prevent -- and, sometimes, even cure -- cancer, as well a variety of other diseases. Dr. Stephen Sinatra -- a board-certified cardiologist -- is a world-renowned expert on CoQ10 and its health benefits.

I beg your to buy and read this book and heed Dr. Sinatra's information and advice.mation packed in. And is very easy to read. I bought this book to see if Q10 would be a usefull treatment for gum disease. One of the key factors that your body is low of Q10. After reading this book and using the tools I learned in there I have increased my health 10 fold. My gum disease has disapeared, I am more alert and sleep more sound. Things I didn't even think Q10 could help with. Not to mention the appearance of my skin overall. I think anyone that is looking to help increase their state of health should read this book.

[grasswire]

8. it was Dr. Sinatra's regimen that made a huge difference...

...in my life. I started down his list of recommended supplements after an ER doc told me to start taking magnesium supplement for arrhythmia and I started researching supplements. I am not fully there yet with Sinatra's recommendations, but have added coq10, vitamin E, the calcium-magnesium-zinc, omega 3 of course, and alpha lipoic. Still need to add some others. Through many years of arrhythmia I felt every day that my heart was giving me grief. I could not walk up a steep hill or flights of stairs without *palpitations*. Now I have no trouble at all. My endurance and energy are greatly improved.

I fired my hotshot cardiologist, who wanted to put me on several extremely expensive meds with nasty side effects.

[wuvuj]

9. I take 50 mg of ubiquinol / day....

...but can't say that I notice a difference...but was also taking 60 mg COQ10 before this.

[HysteryDiagnosis]

10. It is said that some peoples' ability to produce it dwindles as we

age, while others who take statins may have lowered levels due to the medication... some big pharma had a patent to include CoQ10 in the statin it produced 25 or 30 years ago... but they lunched on it probably because of cost.

http://www.communicationagents.com/chris/2003/12/13/statin_drugs_coenzyme_q10_depletion.htm

Statin Drugs & Coenzyme Q10 Depletion
Categories
Control tactics
Health through Nutrition
Practical Health

Update

Thanks to Ron Law, I have included the patent reference below. This patent was issued in 1989 so this is not new news - one can only wonder of the number of people who died from congestive heart and other issues as a result of this shady tactic...

See: Petition by Dr. Julian M. Whitaker, M.D. and a review of pertinent human and animal data.

Further on the theme of, dangerous and useless, Statin Drugs. The following adds another downside as if more are needed - severe nutritional cost of the drug. Merck actually patented (4,933,165) a combination of statin and CQ10 in a pill but never put it on the market, given the marketing shenanigans (patent to prevent others from marketing such a pill) of these scoundrels it is just the thing to do to protect their business with disease.

Now that the cat is out of bag watch them come out with a pill with a good dose of CQ10 and a token statin to salvage the image of statins....

Chris Gupta

..."Statins could initiate and/or accelerate malignant growth by a) blocking the production of Coenzyme Q10, which has been shown to have anti-cancer effects; b) stimulating the growth of new blood vessels that malignancies require to promote their propagation; c) decreasing the cytotoxicity of natural killer cells; d) blocking the production of squalene, an intermediate cholesterol metabolite with anti-cancer activities in animal studies and currently used as adjunctive therapy in treating cancer; e) reducing the production of DHEA, which has been shown to have anticancer and immune stimulating effects in experimental studies."...

High Cholesterol May Protect Against Infections And Atherosclerosis

..."Incredibly Merck formula and Patent rights* for CQ10 were sold to the Japanese circa 1958 as this would compete with their blockbuster drug Diuril. Fortunately, the Japanese were able to synthesize large quantities of this nutrient, where is it has been used for over 30 years as an effective treatment for heart disease."...

GETTING BOOTED FROM A DRUG INDUSTRY-SUPPORTED WEBSITE

..."Statin-induced CoQ10 depletion is well documented in animal and human studies with detrimental cardiac consequences in both animal models and human trials. Furthermore, this drug-induced nutrient deficiency is dose-related and more notable in settings of pre-existing CoQ10 deficiency such as in the elderly and in heart failure."...

CQ10 (coenzyme Q10) and Cancer

CoQ10 Depletion. The Achilles Heel of the Statin Crusade.

Peter H. Langsjoen, M.D., F.A.C.C., Cardiovascular Diseases. Research in Biomedical Aspects of Coenzyme Q10. Tel [phone], Fax [phone] Doctors Dr., Tyler, Texas 75701,USA.

www.coenzymeQ10.org

The depletion of the essential nutrient coenzyme Q10 (CoQ10) by the increasingly popular cholesterol lowering drugs, HMG-CoA reductase inhibitors (statins) has grown from a level of concern to one of alarm. With ever higher statin potencies and dosages, and with a steadily shrinking target LDL cholesterol, the prevalence and severity of CoQ10 deficiency is increasing noticeably to the physicians in the trenches of front line patient care. An estimated 36 million Americans are now candidates for statin drug therapy.

CoQ10 serves as the coenzyme for mitochondrial enzyme complexes I, II and III and is essential for mitochondrial ATP production. CoQ10 is also a clinically relevant fat-soluble antioxidant and is the only fat soluble antioxidant that is known to be synthesized de novo. It is found normally in the diet, predominantly in organ meats and is biosynthesized in all cells with peak capabilities in late teens and early twenties with a gradual age-related decline in blood and tissue CoQ10 levels after the age of 30 years.

Statin-induced CoQ10 depletion has been documented in 15 animal studies in six different animal species and has been shown to correlate with decreased ATP production, increased ischemia reperfusion injury, skeletal muscle injury and increased mortality.

There are 15 published trials on statin-induced CoQ10 depletion in humans. Of these 15 trials, nine were controlled trials, eight of which documented significant CoQ10 depletion. Statin-induced CoQ10 depletion has been shown to be associated with a fall in left ventricular function, an elevation of lactate to pyruvate ratio and an enhancement of LDL cholesterol oxidation. The current data on diastolic dysfunction further confirms the clinical importance of this drug-nutrient interaction.

Statin-induced CoQ10 depletion is well documented in animal and human studies with detrimental cardiac consequences in both animal models and human trials. Furthermore, this drug-induced nutrient deficiency is dose-related and more notable in settings of pre-existing CoQ10 deficiency such as in the elderly and in heart failure. Finally, statin-induced CoQ10 deficiency is completely preventable with supplemental CoQ10 with no adverse impact on the cholesterol lowering or anti-inflammatory properties of the statin drugs.

We are currently in the midst of a congestive heart failure epidemic in the United States, the cause or causes of which are unclear. As physicians, it is our duty to be absolutely certain that we are not inadvertently doing harm to our patients by creating a wide-spread deficiency of a nutrient critically important for normal heart function.