Medscape. Zosia ChusteckaAugust 20, 2008 — "There is good reason to be cautious about introducing large-scale vaccination programs" with the human papillomavirus (HPV) vaccines, because many essential questions are still unanswered. This is the conclusion of Charlotte Haug, MD, PhD, from the Journal of the Norwegian Medical Association, in Oslo, writing in an editorial in the August 21 issue of the
New England Journal of Medicine. "The real impact of HPV vaccination on cervical cancer will not be observable for decades," Dr. Haug comments, but there has been pressure on policy makers worldwide to introduce the HPV vaccine in national or statewide vaccination programs.
...However, Dr. Haug questions how policy makers can make "rational choices about the introduction of medical interventions that might do good in the future but for which evidence is insufficient, especially since we will not know for many years whether the intervention will work or — in the worst case — do harm?"
...In view of all the questions that remain to be answered, Dr. Haug urges more research into HPV vaccination. "We should concentrate on finding more solid answers through research rather than base consequential and costly decisions on yet-unproven assumptions," she concludes.
No conflicts of interests were reported.
N Engl J Med. 2008;359:821-832, 861-862.