PANTETHINE for reducing cholesterol

[Ice4Clark]

I posted this on another thread, but thought I'd post it alone so maybe it would be seen.

I put my husband on this. We'll have his blood checked in a couple months and see what results he has. Here is the link to the product he is using. I chose it because it is what was used in the University of MN's clinical trial. It's pharmaceutical grade. No known side effects.

Endurance Products


Here are some snips of articles I had bookmarked about Pantethine:


Pantethine

Pantethine is a form of pantothenic acid (vitamin B5) that has been shown to lower cholesterol. Specifically, it reduces levels of LDL and total cholesterol, raises HDL, and is the most effective supplement for lowering triglyceride levels. Pantethine works by improving fat metabolism and by slowing down production of cholesterol in the liver.

Pantethine is often recommended for diabetics.

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Pantethine and pantothenic acid, 400 to 900 mg each per day. The use of pantethine to reduce total cholesterol, LDL cholesterol, and triglyceride level, while raising the good HDL cholesterol at the same time, is well documented. Bertolini et al treated a series of 65 adults suffering from hypercholesterolemia alone or associated with hypertriglyceridemia (types IIa and IIb of Fredrickson's classification). Pantethine 1200 mg daily for adults was used for 3 years. In adult population with type IIa hyperlipoproteinemia, the study showed a 25% decrease in total cholesterol, a 39% decrease in LDL-cholesterol, a 34% decrease in Apo-B, and a modest increase in HDL-cholesterol were observed. In adult patients with type IIb hyperlipoproteinemia, total cholesterol was reduced by 19.8%, LDL-cholesterol by 37%, triglycerides by 31%, and Apo-B by 6%. In this subgroup, a 23% increase of HDL-cholesterol and a 15% increase in apolipoprotein A-I were also observed. In another double-blind placebo-controlled study, 29 people with high cholesterol and triglycerides were followed for 8 weeks. The dosage used was 300 mg 3 times daily, for a total daily dose of 900 mg. In this study, subjects taking pantethine experienced a 30% reduction in blood triglycerides, a 13.5% reduction in LDL ("bad") cholesterol, and a 10% rise in HDL ("good") cholesterol. Typically, a daily dose of 900 mg pantethine has been shown to reduce triglyceride by 20-30%, total cholesterol by 10-20%, LDL cholesterol by 10-20%, and a rise in HDL cholesterol by 10-20% in many studies.

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Pantothenic acid supplementation has been proven effective in addressing hyperlipidemia, as its derivatives— including pantethine—lowered total cholesterol and triglycerides in obese mice, 141 and 600 mg/d of pantethine severely reduced fatty liver in 16 hypertriglyceridemic patients.142 A University of Minnesota trial further showed 600 mg/d to 900 mg/d of pantethine (as Pantesin®, from Daiichi Pharmaceutical) improved levels of LDL, VLDL and triglycerides and increased HDL.143

[Fridays Child]

1. This is very interesting.

Could you PM me when you get the follow-up results, in a couple of months? If it works, it might be a good alternative to cholesterol-lowering drugs. Currently, my husband is taking Crestor. Not only is it not on our formulary and very expensive, but I think there may be liver problems associated with it, too.

At the site you linked, I was also reading about phytosterols--apparently, another good cholesterol lowering addition to the supplement regimen.

[tabatha]

2. food sources

Vitamin B-5 or Pantothenic Acid or Pantethine: Best Bet Food Sources-- Blackstrap molasses, eggs, sweet potatoes, oatmeal, soybeans and soybean products.

[kaygore]

3. Great information--thanks