The epidemic of diabetes--and organic pollutants

[Celebration]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16801591&query_hl=4&itool=pubmed_docsum

Diabetes Care. 2006 Jul;29(7):1638-44.

A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002.Lee DH, Lee IK, Song K, Steffes M, Toscano W, Baker BA, Jacobs DR Jr.
Department of Preventive Medicine, School of Medicine, Kyungpook University, 101 Dongin-dong, Jung-gu, Daegu, Korea 700-422. [e-mail]

OBJECTIVE: Low-level exposure to some persistent organic pollutants (POPs) has recently become a focus because of their possible link with the risk of diabetes. RESEARCH DESIGN AND METHODS: Cross-sectional associations of the serum concentrations of POPs with diabetes prevalence were investigated in 2,016 adult participants in the National Health and Nutrition Examination Survey 1999-2002. Six POPs (2,2',4,4',5,5'-hexachlorobiphenyl, 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin, 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin, oxychlordane, p,p'-dichlorodiphenyltrichloroethane, and trans-nonachlor) were selected, because they were detectable in >or=80% of participants. RESULTS: Compared with subjects with serum concentrations below the limit of detection, after adjustment for age, sex, race and ethnicity, poverty income ratio, BMI, and waist circumference, diabetes prevalence was strongly positively associated with lipid-adjusted serum concentrations of all six POPs. When the participants were classified according to the sum of category numbers of the six POPs, adjusted odds ratios were 1.0, 14.0, 14.7, 38.3, and 37.7 (P for trend < 0.001). The association was consistent in stratified analyses and stronger in younger participants, Mexican Americans, and obese individuals. CONCLUSIONS: There were striking dose-response relations between serum concentrations of six selected POPs and the prevalence of diabetes.The strong graded association could offer a compelling challenge to future epidemiologic and toxicological research

PMID: 16801591

[whistle]

1. Well, there you go, diabetes is the patients fault, if they would have

...just avoided those nasty POPs there would be no diabetes epidemic.:sarcasm:

Exactly where do these POPs originate from and how do humans and other animals (dogs, cats, etc.) avoid exposure? Those of us who have been recently diagnosed with diabetes Type 2 would like to know.

<snip>
Cardiovascular and Metabolic Risk
Original Article

OBJECTIVE—Low-level exposure to some persistent organic pollutants (POPs) has recently become a focus because of their possible link with the risk of diabetes.

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Abbreviations: AhR, aryl hydrocarbon receptor • DDE, p,p'-dichlorodiphenyltrichloroethane • HCB, hexachlorobenzene • HpCDD, 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin • LOD, limit of detection • NHANES, National Health and Nutrition Examination Survey • OCDD, 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin • PCB, polychlorinated biphenyl • PCB153, 2,2',4,4',5,5'-hexachlorobiphenyl • PCDD, polychlorinated dibenzo-p-dioxin • PCDF, polychlorinated dibenzofuran • POP, persistent organic pollutant • SUMPOP, sum of POP levels • TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin • TEF, toxic equivalency factor
<more>

http://care.diabetesjournals.org/cgi/content/abstract/29/7/1638

http://news.bbc.co.uk/1/hi/health/4478192.stm