Democratic Underground Latest Greatest Lobby Journals Search Options Help Login
Google

For those who need their livers there is policosanol, fiber,

Printer-friendly format Printer-friendly format
Printer-friendly format Email this thread to a friend
Printer-friendly format Bookmark this thread
This topic is archived.
Home » Discuss » Topic Forums » Health Donate to DU
 
HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-05-06 03:55 PM
Original message
For those who need their livers there is policosanol, fiber,
Edited on Sat Aug-05-06 04:00 PM by 4MoronicYears
chitosan, coenzyme Q10, essential fatty acids and others.... for all the rest there is Lipitor and its cousins.

Please note you will land on page two of this article....

http://www.lef.org/protocols/prtcl-032a.shtml
Benefits of Policosanol
Policosanol is a natural supplement derived from sugar cane. The main ingredient is octacosanol. Octacosanol is an alcohol found in the waxy film that plants have over their leaves and fruit. The leaves and rinds of citrus fruits contain octacosanol, as does wheat germ oil.

Policosanol has been shown to normalize cholesterol as well or better than cholesterol-lowering drugs, without side effects such as liver dysfunction and muscle atrophy (Mas et al. 1999). Efficacy and safety have been proven in numerous clinical trials, and it has been used by millions of people in other countries. Policosanol lowers harmful LDL-cholesterol and raises protective HDL-cholesterol. HDL-cholesterol removes plaque from arterial walls.

Policosanol helps stop the formation of artery lesions (Noa et al. 1995), an effect similar to that of statin drugs. This was proven in studies on rabbits fed a diet designed to create high cholesterol. According to researchers “in most policosanol-treated animals, atherosclerotic lesions were not present, and in others, thickness of fatty streaks had less foam cell layers than in controls” (Arruzazabala et al. 2000).

Policosanol also inhibits the oxidation of dangerous LDL-cholesterol (Menendez et al. 1999), which promotes the destruction of blood vessels by creating a chronic inflammatory response. Oxidized LDL can also provoke metalloproteinase enzymes. (Xu et al. 1999). These enzymes promote blood vessel destruction, partly by interfering with HDL’s protective effect. Studies show that rats treated with policosanol have fewer foam cells, reflecting less inflammatory response and blood vessel destruction (Noa et al. 1996; Lindstedt et al. 1999).


http://www.injuryboard.com/view.cfm/Topic=818
Lipitor, also known as atorvastatin, is a cholesterol lowering medication manufactured by Pfizer Pharmaceuticals. Lipitor belongs to the statin family of cholesterol drugs and is considered a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.

Recently, another statin drug, Baycol, was removed from the market after causing at least 52 deaths. As a result, the safety of all statin drugs has subsequently come into question. While the Food and Drug Administration (FDA) maintains that Lipitor causes considerably fewer adverse side effects than Baycol, the agency acknowledges that Lipitor does pose some risk.

All statins increase a patient's chances of developing myositis and rhabdomyolysis, potentially fatal conditions that cause muscle pain and muscle deterioration and may lead to kidney failure. According to the FDA, the chances of developing myositis or rhabdomyolysis from Lipitor are low. As such, Lipitor remains on the market. See a licensed physician if you have concerns regarding the safety of Lipitor, other statins, or any prescription drug. It should be noted that with the exception of Baycol, most doctors believe that the benefits of statin therapy outweigh the risks associated with this class of drugs.

In July 2004, the FDA approved Lipitor to help reduce the risk of heart attack. The labeling change resulted from a 19,000 patient clinical trial that revealed Lipitor reduced the risk of heart attack and heart-related death by 36 percent compared to a placebo.
Printer Friendly | Permalink |  | Top
niallmac Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-05-06 04:12 PM
Response to Original message
1. I really appreciate learning about alternative drugs
and thank you 4MoronicYears (love the moniker) for presenting the info responsibly.
Printer Friendly | Permalink |  | Top
 
eallen Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-05-06 04:15 PM
Response to Original message
2. Latest studies are showing policosanol doesn't help cholesterol.
I was really disappointed. Recent studies from Germany that use larger numbers of subjects, and done by researchers not connected to the drug's manufacture or distribution, aren't showing an effect. Feh.

:hippie:
Printer Friendly | Permalink |  | Top
 
Agnomen Donating Member (420 posts) Send PM | Profile | Ignore Sat Aug-05-06 04:43 PM
Response to Reply #2
3. There's also red yeast rice - my dr. recommended it
Printer Friendly | Permalink |  | Top
 
HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-05-06 04:52 PM
Response to Reply #2
4. Sorry to hear that...... the University of Kentucky nor the
School of Pharmacy and Physical Sciences at Purdue do not distribute policosanol, it is not a drug, and I hope the Germans are wrong, but it is highly unlikely.


There are certain synergistic effects that only occur when two or more supplements are taken together.... this is seen with B vitamins, and is one of the main reasons you usually see them in a complex. This second paper is describing the use of policosanol with red rice extract and astaxanthin. Astaxanthin is potent antioxidant taken from organically grown algae in Hawaii, under controlled and regulated conditions. Many studies have been done with it.... carpal tunnel syndrome comes to mind... there were/are others.

www.Cyanotech.com



Also, it would appear that policosanol alters the ratio of LDL to HDL... some would choose this if it worked and it was without harmful side effects.... I myself take Beta Sitosterol, and there is ample evidence as to its effects on benign prostatic hypertrophy, cholesterol and several other issues that affect the human machine.

Meta-analysis of natural therapies for hyperlipidemia: plant sterols and stanols versus policosanol.

* Chen JT,
* Wesley R,
* Shamburek RD,
* Pucino F,
* Csako G.

School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907-2091, USA. jtchen@pharmacy.purdue.edu

STUDY OBJECTIVE: To compare the efficacy and safety of plant sterols and stanols as well as policosanol in the treatment of coronary heart disease, as measured by a reduction in low-density lipoprotein cholesterol (LDL) levels. DESIGN: Systematic review and meta-analysis of randomized controlled trials.

PATIENTS: A total of 4596 patients from 52 eligible studies. MEASUREMENTS AND MAIN RESULTS: We searched MEDLINE, EMBASE, the Web of Science, and the Cochrane Library from January 1967-June 2003 to identify pertinent studies. Reduction of LDL levels was the primary end point; effects on other lipid parameters and withdrawal of study patients due to adverse effects were the secondary end points.

Weighted estimates of percent change in LDL were -11.0% for plant sterol and stanol esters 3.4 g/day (range 2-9 g/day <893 patients>) versus -2.3% for placebo (769 patients) in 23 eligible studies, compared with -23.7% for policosanol 12 mg/day (range 5-40 mg/day <1528 patients>) versus -0.11% for placebo (1406 patients) in 29 eligible studies. Cumulative p values were significantly different from placebo for both (p<0.0001). The net LDL reduction in the treatment groups minus that in the placebo groups was greater with policosanol than plant sterols and stanols (-24% versus -10%, p<0.0001). Policosanol also affected total cholesterol, high-density lipoprotein cholesterol (HDL), and triglyceride levels more favorably than plant sterols and stanols. Policosanol caused a clinically significant decrease in the LDL:HDL ratio. Pooled withdrawal rate due to adverse effects and combined relative risk for patients who withdrew were 0% and 0.84, respectively (95% confidence interval 0.36-1.95, p=0.69), for plant sterols and stanols across 20 studies versus 0.86% and 0.31, respectively (95% CI 0.20-0.48, p<0.0001), for policosanol across 28 studies. CONCLUSION: Plant sterols and stanols and policosanol are well tolerated and safe; however, policosanol is more effective than plant sterols and stanols for LDL level reduction and more favorably alters the lipid profile, approaching antilipemic drug efficacy.

PMID: 15767233


Sometimes the synergistic effect of two or more supplements can achieve what one alone cannot.

Antiatherosclerotic efficacy of policosanol, red yeast rice extract and astaxanthin in the rabbit.

* Setnikar I,
* Senin P,
* Rovati LC.

Rotta Research Laboratorium, Division of Rottapharm SPA, Monza, Italy. ivo.setnikar@rotta.com

The effects of policosanol (P), of extract of red yeast rice (rice fermented with Monascus purpureus) (RYE) and of astaxanthin (A) (constituents of Armolipid) were investigated in a model of experimental atherosclerosis provoked in the rabbit by atherogenic cholesterol-enriched feed (ACEF). P and RYE and their combination were able to lower the increase of serum total cholesterol and of LDL cholesterol elicited by 3-month feeding with ACEF. They also were able to reduce the increase of blood malondialdehyde (MDA), a tracer of lipid peroxidation by the free radicals released by ACEF. When combined, the substances developed either additive or potentiated effects, supporting the rationale of their combination. Remarkable was the protective effect on lipid infiltration in the aortic wall provoked by ACEF, which was reduced by P and by RYE and almost completely prevented by the addition of A to the P-RYE combination. The results support the rationale of a combination of P, RYE and A as a useful food supplement in hyperlipemic patients.

PMID: 16032970

Printer Friendly | Permalink |  | Top
 
Reckon Donating Member (729 posts) Send PM | Profile | Ignore Sat Aug-05-06 04:52 PM
Response to Original message
5. Niacin
Edited on Sat Aug-05-06 04:56 PM by Reckon
is one of the better alternatives along with policosanol at lowering cholesterol.

The Pharms pay for studies that discredit alternatives so beware of what studies you believe.

Printer Friendly | Permalink |  | Top
 
HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-05-06 04:57 PM
Response to Reply #5
6. I personally believe that the processed food industry has provided
Edited on Sat Aug-05-06 05:03 PM by 4MoronicYears
most of the disease states we deal with today (mainly the degenerative types and the ones that hinge on a screwed up immune system) and the pharmcos are working "feverishly" to correct this fact. Most of the stuff we need to remain well can be found in the kitchen cupboard... well, certainly in mine. (grammatical faux pax noted)

Daily I take:

300 mg time release Lipoic Acid

50 mg pycnogenol

B-Complex

500 mg L-Glutamine

2 grams Beta Sitosterol

A "green drink" in the AM

200 mg coenzyme Q10

Calcium WITH magnesium (don't do dairy)

I feel fine.... and I am old enough to remember when 4 dead in Ohio was a headline and a song by Neil Young.
Printer Friendly | Permalink |  | Top
 
Reckon Donating Member (729 posts) Send PM | Profile | Ignore Sat Aug-05-06 05:41 PM
Response to Reply #6
7. I did take a very extensive regiment
of supplements daily. I've cut back to alternating days and weeks.

I would recommend taking MSM with ALA.

Be careful with the L-Glutamine if you have headaches or if you get a knock on the head.

Make sure your green tea is made with un-chlorinated water.

You might Google those tips.







Printer Friendly | Permalink |  | Top
 
HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-05-06 05:44 PM
Response to Reply #7
8. 10/4, thanks for the "heads up".... :)
Printer Friendly | Permalink |  | Top
 
BuddhaGirl Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-06-06 03:47 PM
Response to Reply #7
11. I see MSM is on your list
I have been taking it for a few months now; it is a great anti-inflammatory. I used to wake up every morning with stiff and sore fingers on one hand (I'm 44) but no longer since starting on MSM.

I use a powder form, a lignisul type of MSM, which is supposed to be a superior form. I think taking MSM daily would be a good way to combat inflammation in general - there's lots of evidence showing the correlation of inflammation to certain diseases, like diabetes, arthritis, heart disease, dementia, etc.
Printer Friendly | Permalink |  | Top
 
FlaGranny Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-12-06 11:55 AM
Response to Reply #11
14. Believe it or not
Edited on Sat Aug-12-06 11:58 AM by FlaGranny
but MSM cured my toenail fungus. I was taking it for muscle stiffness and found that it helped, but one day about 4 or 5 months after being on it, I noticed the fungus was clearing up. I said "what the????" and started researching MSM and found that claim about it. It makes sense. Sulfur is an antifungal used in prescription meds.

Edit: Regarding the policosanol, my husband has been taking it. A friend told him to try it for his prostate troubles. Anyway, since he has been taking it, his cholesterol values have improved significantly with no dietary or medication changes. I'm not sure how much it helped his prostate. It must be doing something for him because when he runs out, he buys more.
Printer Friendly | Permalink |  | Top
 
sgxnk Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-05-06 05:54 PM
Response to Reply #6
9. those are some good things
fwiw, i hope you are taking an "R" isomer of alpha lipoic acid
imo, look into ALCAR (acetyl l-carnitine). this works very well, and synergystically with R-ALA



Printer Friendly | Permalink |  | Top
 
HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-05-06 07:18 PM
Response to Reply #9
10. If I might say, I am using Jarrow's now... time released, seems to
be a bit easier on my digestive system. Let me check..... it doesn't say, but it has Biotin added to it to enhance its activity.... I feel pretty good on it... I have seen acetyl L-carnitine in Walmart, and I noticed that Rexall adds L-Carnitine to its 50mg line of CoQ10.... (Acetyl for brain) (L) for energy production.
Printer Friendly | Permalink |  | Top
 
RedEarth Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-07-06 10:18 AM
Response to Reply #5
12. Caution.........Niacin can also be very harmful to your liver
Edited on Mon Aug-07-06 10:30 AM by RedEarth
If a person is taking niacin in an effort to control their cholestrol they need to have their liver function checked every few months and they need to do this under a doctors supervision. You need to be very careful with niacin.

Dr. Weil's is a good site and also has various suggestions for controlling cholesterol. He too has mentioned the jury is still out on the effectiveness of policosanol.
Printer Friendly | Permalink |  | Top
 
trotsky Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-07-06 10:51 AM
Response to Reply #12
13. Not to mention many, many, "natural supplements"
http://www.aidsmeds.com/LESSONS/Hepatotoxicity9.htm

Herbs to avoid – herbs with known liver toxicity:
Alpine cranberry (Vaccinium vitis-idaea), mercury herb (Mercurialis annua), sweet clover (Melilotus officianalis), trailing arbutus (Epigae repens), woodruff (Galium odorata), cayenne, schissandra chinensis, tonka beans (Dipteryx odorata), witch hazel (Hamamelis virginiana), and kinnik-kinnik or bear berry (Arctostaphylos uva-ursi).

Herbs to avoid – herbs with possible liver toxicity:
Plants of the Senecio, Crotolaria, and Heliotropium genera, alkanna (Alkanna tinctoria), chaparral (Larrea tridentata), comfrey (Symphytum officinale and S. uplandicum), dusty Miller (Senecio cineraria), forget-Me-Not (Myosotis cineraria), groundsel (Senecio vulgaris), borage (Borago officianalis), colts foot (Tussilago farfara), Dong Quai (Angelica polymorpha), ephedra also known as Ma Huang or Mormon tea (Ephedra sinica), germander (Teucrium chamaedrys), hemp agrimony (Eupatorium cannabinum), hops (Humulus lupulus), life root (Senecio aureus and S. nemorensis), mistletoe (Phoradendron leucarpum and Viscum album), petasites (Petasites hybridus), ragwort (Senecio jacobea), sassafras (Sassafras albidum), yohimbe (Pausinystalia yohimbe), Jin Bu Huan (Lycopodium serratum), pennyroyal (Mentha pulegium), pokerroot (Phytolacca americana), rue (Ruta graveolens), skullcap (Scutellaria laterfolia).
Printer Friendly | Permalink |  | Top
 
FlaGranny Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-12-06 12:02 PM
Response to Reply #13
15. Oh my, do I have to stop putting
Edited on Sat Aug-12-06 12:03 PM by FlaGranny
pepper on my food?
Beer is bad too?

Oh dear. My hubby especially won't like the beer part. ;-)
Printer Friendly | Permalink |  | Top
 
DU AdBot (1000+ posts) Click to send private message to this author Click to view 
this author's profile Click to add 
this author to your buddy list Click to add 
this author to your Ignore list Wed Apr 17th 2024, 07:51 PM
Response to Original message
Advertisements [?]
 Top

Home » Discuss » Topic Forums » Health Donate to DU

Powered by DCForum+ Version 1.1 Copyright 1997-2002 DCScripts.com
Software has been extensively modified by the DU administrators


Important Notices: By participating on this discussion board, visitors agree to abide by the rules outlined on our Rules page. Messages posted on the Democratic Underground Discussion Forums are the opinions of the individuals who post them, and do not necessarily represent the opinions of Democratic Underground, LLC.

Home  |  Discussion Forums  |  Journals |  Store  |  Donate

About DU  |  Contact Us  |  Privacy Policy

Got a message for Democratic Underground? Click here to send us a message.

© 2001 - 2011 Democratic Underground, LLC