Sterility in frogs caused by environmental pharmaceutical progestogens

[OKIsItJustMe]

http://www.eurekalert.org/pub_releases/2011-02/uu-sif021611.php

Public release date: 16-Feb-2011

Contact: Cecilia Berg
[e-mail]
46-730-459-246
http://www.uu.se/">Uppsala University

Sterility in frogs caused by environmental pharmaceutical progestogens

Frogs appear to be very sensitive to progestogens, a kind of pharmaceutical that is released into the environment. Female tadpoles that swim in water containing a specific progestogen, levonorgestrel, are subject to abnormal ovarian and oviduct development, resulting in adult sterility. This is shown by a new study conducted at Uppsala University and published today in the scientific journal Aquatic Toxicology.

Many of the medicines that people consume are released into the environment via sewage systems. Progestogens are hormone preparations used in contraceptives, cancer treatment and hormone replacement therapy for menopausal discomfort. Different kinds of progestogens have been identified in waterways in a number of countries. Associate professor Cecilia Berg and doctoral student Moa Kvarnryd at the Department of Environmental Toxicology at Uppsala University have shown that levonorgestrel can cause sterility in female frogs at concentrations not much higher than those measured in the environment. The research group is part of MistraPharma, one of the world's largest research networks focusing on pharmaceuticals and the environment.

"The findings represent important initial evidence that an environmental progestogen can adversely affect frogs," says Cecilia Berg.

Female tadpoles that swam in water containing low concentrations of levonorgestrel exhibited a greater proportion of immature ovarian egg cells and lacked oviducts, entailing sterility. The African clawed frog (Xenopus tropicalis) served as the model organism. It is during the tadpole stage that development of frog reproductive organs begins. The process is governed by the hormone system. The findings underscore the importance of studying how pharmaceuticals affect animals in our environment, which is one objective of MistraPharma.

"Our findings show that pharmaceuticals other than oestrogen can cause permanent damage to aquatic animals exposed during early life stages," says Cecilia Berg.

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Aquatic Toxicology Reference: doi:10.1016/j.aquatox.2011.02.003

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4G-525YP0W-2&_user=681878&_coverDate=02%2F15%2F2011&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000037398&_version=1&_urlVersion=0&_userid=681878&md5=83ed4c9c69ffc9abe1651ad6e79a00ca&searchtype=a

[Urban Prairie]

1. This can't possibly be true, we human parasites can't affect planet Earth

in a way that disrupts/changes its climate or pollutes its rivers and poisons its water tables underground or within the seven seas, just ask any rightwinger.

:sarcasm:

In fact, we should name that gigantic mass of plastic and trash that is ever-degrading while growing larger every day, that is located in between Hawaii and California in the North Pacific, in honor of George W. Bush, calling it Smirkyland, and later make it our 51st state, and perhaps the most densely thick portion of it could have a monument planted in the goo, named after Dick Cheney, like Cheneyville.

[northoftheborder]

2. Love your Smirkyland and other imagery!

[DCKit]

3. But neither is it the only "active" chemical out there.

Atrazine (herbicide) is still my personal favorite.