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You're a Neanderthal: Genes say yes — a little bit

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David Zephyr Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 03:40 PM
Original message
You're a Neanderthal: Genes say yes — a little bit
Source: AP

WASHINGTON – We have met Neanderthal and he is us — at least a little. The most detailed look yet at the Neanderthal genome helps answer one of the most debated questions in anthropology: Did Neanderthals and modern humans mate?

The answer is yes, there is at least some cave man biology in most of us. Between 1 percent and 4 percent of genes in people from Europe and Asia trace back to Neanderthals.

"They live on, a little bit," says Svante Paabo of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany.

Researchers led by Paabo, Richard E. Green of the University of California, Santa Cruz, and David Reich of Harvard Medical School compared the genetic material collected from the bones of three Neanderthals with that from five modern humans.

Their findings, reported in Friday's edition of the journal Science, show a relationship between Neanderthals and modern people outside Africa, Paabo said.



Read more: http://news.yahoo.com/s/ap/20100506/ap_on_sc/us_sci_neanderthal_genes



This is actually very big news and turns on its head earlier assumptions that there was no gentic link between us. Fascinating.
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Deep13 Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 03:46 PM
Response to Original message
1. Here's further evidence:


If Europeans and Asians are part Neanderthal and Africans are not, doesn't that eman Black people are the master race, being the most genetically pure humans and all.
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Ter Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 01:20 PM
Response to Reply #1
55. Neanderthals are 100% pure humans as well, just a different sub-species
Just saying. :)
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McCamy Taylor Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 03:52 PM
Response to Original message
2. I have been saying this for years. If you look at the cranio-facial characteristics of
Neanderthal and compare it to Europeans, you can see the resemblence.

Hot damn! We're cavemen!
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roguevalley Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 04:31 PM
Response to Reply #2
11. they have found transitional skeletal remains of this in caves in
Edited on Thu May-06-10 04:32 PM by roguevalley
the levant. ISkeletal remains in Israel shows children with features of both. I want to enter a HUGE bitch here: even modern documentaries showing neandertal people lurching around in unkempt hair and raw skins draped over their bodies, their arms and legs exposed in minus blizzardy weather. This is such bullshit. I cannot tell you how angry it makes me to see this portrayal. No one living in weather like this, and I speak from experience here, could survive in it like that.
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AlbertCat Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 04:32 PM
Response to Reply #2
12. Neanderthal and compare it to Europeans, you can see the resemblence.
Having never seen a real Neanderthal, I wouldn't know. Were did you see one?

I dunno...broad flat noses don't seem too European and Asian to me, but Neanderthals supposedly had them....


Anyway...


ARE YOU KIDDING????? :eyes:
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Bonobo Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 07:46 PM
Response to Reply #12
39. Completely wrong. They did NOT have flat noses. In fact, Neanderthal noses
were quite pulled out from their face and NOT flat.
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PassingFair Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 04:38 PM
Response to Reply #2
13. Yes, we've know this for years...
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htuttle Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 07:49 PM
Response to Reply #13
40. Hey, a little RESPECT please!

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Autonomy Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 04:46 PM
Response to Reply #2
18. That may be true for a small portion of phenotypical atavisms
Edited on Thu May-06-10 04:54 PM by Autonomy
iow, those who express the Paleolithic ancestors as opposed to the Neolithic ancestors. Class structures and caste structures may have some root in this distinction, though I admit it would be a stretch to prove.

edit: added qualifier
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IthinkThereforeIAM Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 03:54 PM
Response to Original message
3. I have always felt there was a recessive gene...

...that would show up from time to time, everyone knows of a family where one of the family members just doesn't look anything at all like the rest of the family, feature wise, and it wasn't due to "wild oats". Heavy brows, peculiar body form, etc.
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AlbertCat Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 04:38 PM
Response to Reply #3
14. one of the family members just doesn't look anything at all like the rest
I'll bet you can tell a Jew just by the shape of their head!


This "they look like a Neanderthal" crap is so embarrassingly stupid, I wish you guys would quit it.


Cheesus! :eyes: :eyes: :eyes:
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proudohioan Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 03:55 PM
Response to Original message
4. Fascinating! Thank you for the OP....
Funny, My SO and I were having the Neanderthal/Modern Human "did they mate and produce" debate just last weekend! I can't wait for him to get home and show him the article!

Thank you again!
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David Zephyr Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 11:01 PM
Response to Reply #4
48. I've long argued we mated but could not yield offspring.
This turns everything upside down. But it does make me happy. They were before us and were spread clear to Siberia.
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proudohioan Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 01:05 PM
Response to Reply #48
54. That was SO's position, too....
or if offspring were in fact produced, they would be sterile, like mules.

What an exciting discovery!
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happyslug Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 04:04 PM
Response to Reply #54
60. Mules can be fertile
Occasionally a Female Mule produces an offspring. Given the mule itself is a product of a horse (Mare) and a Donkey (sire), we are talking of a mule sired with a Donkey. The product is either a Donkey or another mule. Some genes may be exchanged but unlikely.

Please note I mentioned Female Mules, male mules are generally gelded for the same reason males horses are, it removes the sex drive and makes them easier to work with (i.e. no fighting among the males to be top male. Since gelding is relatively easy to do, it is done on almost all male mules. Female mules are left "intact" for the spraying a female horse or mule is much more difficult and more likely to end up killing the horse or mule AND the benefit of having a calmer animal is NOT a product of the spraying. Thus we have female mules that produce off spring but no stories of male mules producing off spring.

For more see the reports on Hinnys (Mules with Horses as Mothers and Donkeys as fathers, the opposite of true mules):
http://en.wikipedia.org/wiki/Hinny

More on Mules:
http://en.wikipedia.org/wiki/Mule
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proudohioan Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 06:46 PM
Response to Reply #60
62. Thank you for the info....
I was under the mistaken idea that mules were sterile.
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CreekDog Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 03:56 PM
Response to Original message
5. Some more than others
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aquart Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 03:59 PM
Response to Original message
6. It was always ridiculous to say we didn't mate with Neanderthals.
We do sheep.
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ixion Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 04:02 PM
Response to Reply #6
8. exactly
History shows we mate with just about anything. Why should Neanderthals be exempt? :evilgrin:
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AlbertCat Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 04:42 PM
Response to Reply #6
16. We do sheep.
But we don't have fertile offspring with sheep.

THAT was the main question. Could such a coupling produce fertile offspring?
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aquart Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 05:22 PM
Response to Reply #16
24. Well, polar bears are screwing brown bears because they need a new species quick.
So I'd say yes.

And, of course, one could ask: Goat god Pan, myth or memory?
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Codeine Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 07:28 PM
Response to Reply #16
67. We're the same species
as Homo sapiens neanderthalensis as far as most scientists are concerned. Assuming this view is accurate then they were a different sub-species, but that is no barrier to inter-breeding.
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Botany Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 04:00 PM
Response to Original message
7. Mike Huckabee's kid .... the missing link?
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OnyxCollie Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 05:06 PM
Response to Reply #7
21. Ouch!
Is that his mug shot from when he hanged the dog?

Dad cooks squirrels in a popcorn maker; kid looks and acts like a barbarian. You might be on to something!
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McCamy Taylor Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 04:09 PM
Response to Original message
9. Here is another prediction. They will eventually decide that 100% Neanderthal went extinct because
of intermittent long winters like the one that struck the world in 70,000 BC when Mount Toba erupted, sending the world into a 30 year winter. This is because Neaderthal did not eat fish. When the sun did not shine for a few years, their children would not have been able to get the necessary Vit. D for bone growth and so they would have developed ricketts. Also, there would have been less prey to hunt (Neanderthal were meat eaters and with the massive vegetation kill, the earth would not have been able to support as many large animals). However, people who lived beside hot springs would have had 1) geothermal energy to help them survive the cold 2) plenty of food since the hot springs could nourish and support algae type vegetable matter, food and beetles in the absence of solar energy. Fish are a good source of Vit D. Modern cro-magnon have been fish eaters for a very, very long time.


Note that they have found signs of continuous human occupation before and after Mount Toba in two regions of the world, one in Africa in Uganda (where hot springs are present) and the other in a part of India where hot springs are also present.

I suspect that cro-magnon won out in the end, because they are so adaptable. However, there are certain Neanderthal characteristics that would have been beneficial in Europe and extreme latitudes. Heavier bones help mountain dwellers. And the larger noses/airways would have made it easier to breathe inside smoke filled caves. Since people with these Neanderthal characteristics had a slight advantage in a few niches, some of their genes would have been preserved.

Just a theory, but I am almost certain that I am right.
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AlbertCat Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 04:45 PM
Response to Reply #9
17. This is because Neaderthal did not eat fish.
And you know this.... how?

I assure you, those that lived near water probably ate fish.

And when did all Neanderthals start doing the exact same things everywhere they lived?


I am almost certain that you are confused.
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grantcart Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 07:54 PM
Response to Reply #9
41. Isn't there a scholarly consensus that Neanderthal lost the competiton for
control of territory because their heavier skeleton made them much slower and they had less language development for coordinated attack?
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Codeine Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 07:14 PM
Response to Reply #9
64. What makes you think they didn't eat fish?
They would have eaten whatever they could get.
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fascisthunter Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 04:25 PM
Response to Original message
10. that explains FreeRepubiks
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Autonomy Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 04:38 PM
Response to Original message
15. This makes white people the "older" race
at least in part, contrary to contemporary wisdom. We've heard for quite a while that Africa has more genetic diversity because of the length of time in which people have lived there. This finding will change that a fair bit. It seems likely that there was some sort of genetic bottleneck 'after' the interbreeding with Neanderthal that accounts for 'some' of the decreased diversity in Europeans. Just a guess.
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AlbertCat Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 04:49 PM
Response to Reply #15
19. This makes white people the "older" race
Edited on Thu May-06-10 04:50 PM by AlbertCat
The complete stupidity on this subject displayed here is mind boggling.

(Maybe it's the inferior Neanderthal part of your brain causing it!)



(BTW... all white people, like blacks and asians, are Homo Sapiens, not Neanderthals)
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Autonomy Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 08:57 PM
Response to Reply #19
47. Neanderthals were Homo Sapiens, too
Edited on Thu May-06-10 09:00 PM by Autonomy
It's non-controversial that African peoples are an 'older' race because of the genetic diversity in Africa. There is 'some' constructed nature in that statement, but it's also insightful; it's one of the main facts used to come up with the "Out of Africa" theory. Homo Sapien Neanderthalensis is MUCH older than Homo Sapiens Sapiens (both are Homo Sapiens, btw), so any population with Neanderthal lineage would be 'partially' older than any population without.

Also, it's racist and unsupported ignorance to assume that Neanderthals are "inferior" (we are the same species, as evidenced by the interbreeding). The fact that Neanderthals are extinct does not excuse bigotry. They surely had a 'differential' set of skills and talents than modern humans.

I'm guessing you don't really know much about the subject, and your post is uncomfortable overreaction.
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Xipe Totec Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 04:57 PM
Response to Original message
20. Too easy nt
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dipsydoodle Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 05:09 PM
Response to Original message
22. Posted earlier in the day
in the Science Forum - where it belongs.
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Ian David Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 05:12 PM
Response to Original message
23. So much for the "racial purity" or the "white race." They're the ones who fucked the Neanderthals.nt
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daleo Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 06:07 PM
Response to Reply #23
26. People will boast about their "hybrid vigor"
If they are so inclined. These categorizations are infinitely elastic. Racists can make any set of facts fit their preconceptions.
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Ian David Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 06:20 PM
Response to Reply #26
28. You're right. I forgot that one should never underestimate the mental gymnastics of racists.
I forgot the way the Nazis had to invent a whole new Atlantis mythos to make their racist ideas "work."

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1monster Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 07:15 PM
Response to Reply #23
35. You all are laboring under a misapprehension. "White" people are "white" because of a
Edited on Thu May-06-10 07:16 PM by 1monster
genetic mutation. We all descend from "brown" people.

http://www.washingtonpost.com/wp-dyn/content/article/2005/12/15/AR2005121501728.html

Scientists Find A DNA Change That Accounts For White Skin

By Rick Weiss
Washington Post Staff Writer
Friday, December 16, 2005

Scientists said yesterday that they have discovered a tiny genetic mutation that largely explains the first appearance of white skin in humans tens of thousands of years ago, a finding that helps solve one of biology's most enduring mysteries and illuminates one of humanity's greatest sources of strife.

The work suggests that the skin-whitening mutation occurred by chance in a single individual after the first human exodus from Africa, when all people were brown-skinned. That person's offspring apparently thrived as humans moved northward into what is now Europe, helping to give rise to the lightest of the world's races.

Leaders of the study, at Penn State University, warned against interpreting the finding as a discovery of "the race gene." Race is a vaguely defined biological, social and political concept, they noted, and skin color is only part of what race is -- and is not.

In fact, several scientists said, the new work shows just how small a biological difference is reflected by skin color. The newly found mutation involves a change of just one letter of DNA code out of the 3.1 billion letters in the human genome -- the complete instructions for making a human being.


http://boingboing.net/2005/12/16/dna-mutation-account.html etc., etc., etc.,



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Ian David Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 07:21 PM
Response to Reply #35
36. But were Europeans "white" 20,000 years ago?



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1monster Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 07:42 PM
Response to Reply #36
38. I don't understand your question. The article said the mutation happened TENS OF THOUSANDS of
years ago, so I guess it is possible that 20,000 years ago, those living in Europe were predominately "white."
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Ian David Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 08:05 PM
Response to Reply #38
44. Got it. I'm slow tonight. Thanks. n/t
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Psephos Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 01:58 AM
Response to Reply #23
49. You've got that rather backwards.
Modern Caucasians originally hail from Africa. Dark skin pigmentation was lost as African humans migrated to more northerly latitudes about 60,000 years ago. Pale-skinned Homo sapiens neanderthalus were already there as the Africans encroached into the northlands to establish the "European races."

"White race" is a gallimaufry term at best.

I put "human race" on my Census form and I look forward to the day when that realization becomes universal.
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abelenkpe Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 05:55 PM
Response to Original message
25. What?
I thought the earth was only 5000 years old, evolution was a hoax and humans and dinos wandered around together in harmony. It's in a museum and everything.....


:evilgrin:
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No Elephants Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 06:18 PM
Response to Original message
27. Clan of the Cave Bear, published in 1980, describes mating of a
Neanderthal male and a "homo" sapiens female. It was a book of fiction.

Still.....
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daleo Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 06:36 PM
Response to Reply #27
30. I remember that book
It was interesting.
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Codeine Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 07:30 PM
Response to Reply #27
68. To be fair,
those books never missed an opportunity to throw in as many sex scenes as humanly possible, so it was inevitable that they'd toss in a "flathead" scene. :evilgrin:
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Lydia Leftcoast Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 06:29 PM
Response to Original message
29. The Neanderthals lived in precisely the same area where
such features as blue eyes and light-colored skin are found.
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nsd Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 06:38 PM
Response to Reply #29
31. Neandertal fossils have been found not only in Europe but in western Asia.
In fact, it's thought that they ranged as far east as Iran/Afghanistan. Also, in the paper, the authors found that individuals from China and Papua New Guinea were as closely related to Neandertals as Europeans.

So the link to light-colored skin is unlikely.

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Lydia Leftcoast Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 06:48 PM
Response to Reply #31
32. But Iran and Afghanistan do have people with light skin and blue eyes.
:eyes:
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nsd Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 06:56 PM
Response to Reply #32
34. True, but Papua New Guinea does not.
Edited on Thu May-06-10 07:47 PM by nsd
The authors found the Papuan and Chinese individuals were as closely related to Neandertal as the French individual was. They speculate that mixing happened in the Middle East, before the ancestors of modern non-Africans spread throughout Eurasia (50,000 to 100,000 years ago).

Present-day differences in skin color are generally thought to have evolved much more recently -- long after this period.

ETA: More specifically, skin lightening is thought to have occurred as a consequence of living in the cooler climates of Eurasia, not because that's how people looked when they set off for Europe and northeast Asia.
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Codeine Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 07:21 PM
Response to Reply #32
65. That almost certainly has more to do with
Greek/Macedonian settlements and governance in those areas conquered by Alexander than with any imagined Neanderthal connection.

A thumbnail overview:

http://en.wikipedia.org/wiki/Hellenistic_civilization
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depakid Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 06:48 PM
Response to Original message
33. I've long thought some lived on in Milford Wolpoff
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Kablooie Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 07:33 PM
Response to Original message
37. Impossible! Neanderthals lived 30,000 years ago. That's 24,000 years before God made the world.
So there's no way humans could have interbred with them.
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bleever Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 07:54 PM
Response to Original message
42. I'm no scientist,
but I have always suspected that the possibility of zero interbreeding was quite remote.

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proteus_lives Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 04:20 PM
Response to Reply #42
61. "And now he's a lawyer...."
I loved that skit.

RIP Mr. Hartman.
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AlphaCentauri Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 08:01 PM
Response to Original message
43. Back then, did they have a rent a Neanderthal website? eom
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NeoGreen Donating Member (299 posts) Send PM | Profile | Ignore Thu May-06-10 08:18 PM
Response to Original message
45. How many chromosomes did the Neanderthals have?
Isn't there a difference in the number of chromosomes between humans and the Great Apes (Chimps, Bonobo, Gorillas and Orangutans)? I think we have one fewer. How many did the Neanderthals have?

Just curious, I'm off to google to see if I can find out.
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Jade Fox Donating Member (1000+ posts) Send PM | Profile | Ignore Thu May-06-10 08:51 PM
Response to Original message
46. But how did ALL the genes end up in Joe the Plumber?
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Psephos Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 02:07 AM
Response to Original message
50. Rosanna Arquette is a reasonable example of how Neanderthals actually looked.
She more closely resembles the Neanderthal phenotype than the ridiculous Geico characters or the ridiculous pop culture stereotype that everyone repeats.
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Bonobo Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 04:25 AM
Response to Reply #50
52. Quite right.
Edited on Fri May-07-10 04:26 AM by Bonobo
Pulled out face. Like this:

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New Dawn Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 02:11 AM
Response to Original message
51. Incredible results. Even 1% would be far higher than probably most researchers would have guessed.
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E-Z-B Donating Member (438 posts) Send PM | Profile | Ignore Fri May-07-10 06:36 AM
Response to Original message
53. Exactly as our ancestors in Battlestar Galactica wanted.
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Coco2 Donating Member (52 posts) Send PM | Profile | Ignore Fri May-07-10 03:08 PM
Response to Original message
56. That makes Africans the only 'humans' and all others hybrids!
Talk about your irony. Centuries of being classed as sub-human only to find out you are the ONLY humans. LOL Also that means that either god was Black or he was a hybrid, afterall according to the book man was made in his image. NEWS HEADLINE: KKK heads explode and bodies spin in graves! Film at 11
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LuckyTheDog Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 03:24 PM
Response to Original message
57. TEA PARTIES EXPLAINED! (nt)
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LuckyTheDog Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 03:37 PM
Response to Original message
58. Having sex with modern human women...
... it's SO EASY A CAVEMAN CAN DO IT!


:rofl:
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htuttle Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 07:48 PM
Response to Reply #58
69. Dammit!


I'm out of here...
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happyslug Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 03:51 PM
Response to Original message
59. Duplicate Subject this one 2:28 pm from May 6, 2010
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IndianaGreen Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 07:02 PM
Response to Original message
63. Only white and Asian peoples are Neanderthal
People from Africa are pure homo sapiens!

:P
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Codeine Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 07:23 PM
Response to Reply #63
66. Neanderthal was homo sapiens too.
Homo sapiens neanderthalensis
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New Dawn Donating Member (1000+ posts) Send PM | Profile | Ignore Fri May-07-10 10:13 PM
Response to Reply #66
70. That is disputed.
Edited on Fri May-07-10 10:14 PM by New Dawn
In any case, Neanderthals and humans did have similar levels of intelligence, technology, and culture when they coexisted. That is the most important thing to keep in mind.
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