On June 26, 1904, Peter Lorre was born.

[mahatmakanejeeves]

Actor Peter Lorre was #BornOnThisDay, June 26, 1904. Fled Nazi Germany due to his Jewish heritage, first to Paris, then to England & eventually to America & international fame as a film star & great actor. Passed in 1964 (age 59) from a stroke.#RIP #GoneTooSoon #birthday #BOTD

Link to tweet

[underpants]

1. On a morning from a Bogart movie

On a morning from a Bogart movie
In a country where they turn back time
You go strolling through the crowd like Peter Lorre
Contemplating a crime
She comes out of the sun in a silk dress running
Like a watercolor in the rain
Don't bother asking for explanations
She'll just tell you that she came
In the year of the cat

[mahatmakanejeeves]

2. Great link. Thanks.

[bucolic_frolic]

3. Hard to realize how poor preventive medicine was mid-century

blood pressure meds came in, when? I don't know. 1980s?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763852/

It is surprising that only about 50?years ago hypertension was considered an essential malady and not a treatable condition.

https://www.invent.org/inductees/frederick-novello

Frederick Novello

Thiazide Diuretics (Chlorothiazide)
U.S. Patent No. 2,809,194
Inducted in 2019
Born 1916 - Died Dec. 17, 1986

In 1943, scientist Frederick Novello embarked on a 38-year career with Merck Sharp & Dohme, working on compounds for the development of new drugs as a senior investigator in the medicinal chemistry department. One of his key achievements — in collaboration with fellow organic chemist James Sprague and pharmacologists John Baer and Karl Beyer — was the invention of thiazide diuretics, the first class of drugs to safely and effectively treat hypertension.

When chlorothiazide was introduced in 1958, heart disease was the leading cause of death in the United States, with millions of Americans suffering from some form of hypertension. Until then, the only effective medications for treating hypertension were difficult to use and had toxic side effects. Chlorothiazide, the first diuretic to inhibit the reabsorption of sodium and chloride ions in the kidneys and increase urine production without upsetting electrolyte balance, was a safe and effective alternative.

In 1967, a landmark study of Veterans Administration patients with high blood pressure showed that thiazides dramatically reduced cardiovascular events, hospitalization and sudden death. Today, thiazide diuretics remain a first-line treatment for high blood pressure and related heart problems, and for decreasing edema. They are often used in combination with drugs from other classes to combat hypertension.