Genetics in focus after coronavirus deaths of siblings and twins
Amid the steady stream of stories on the lives lost to coronavirus are cases that stand out as remarkable. In the past month, at least two pairs of twins have died in Britain and two pairs of brothers, all within hours or days of each other. But do the deaths point to genetic factors that make some more likely than others to succumb to the disease?
Most scientists believe that genes play a role in how people respond to infections. A person’s genetic makeup may influence the receptors that the coronavirus uses to invade human cells. How resilient the person is to the infection, their general health, and how the immune system reacts will also have some genetic component.
A team led by Prof Tim Spector, head of twin research and genetic epidemiology at King’s College London, has reported that Covid-19 symptoms appear to be 50% genetic. But Spector said more work is needed to understand which genes are involved and what difference they make to the course of the disease. “We don’t know if there are genes linked to the receptors or genes linked to how the infection presents,” he said.
Identical twins Katy and Emma Davis, aged 37, died at Southampton general hospital last month. The sisters, who lived together, had underlying health problems and had been ill for some time before they contracted the virus. Another pair of twins, Eleanor Andrews and her sister Eileen, aged 66, died earlier this month. They too lived together and had underlying health conditions.
https://www.theguardian.com/world/2020/may/05/genetics-in-focus-after-coronavirus-deaths-of-siblings-and-twins
