General Discussion
Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsTreatment of 5 critically ill COVID patients with convalescent plasma (JAMA)
Link to tweet
*Preliminary* #COVID19 study in
@JAMA_current
- 5 critically ill pts. on mechanical ventilation
- All treated w/ convalescent plasma w/ #SARSCoV2 antibody
- In 4/5, SOFA score⬇, viral loads⬇, ARDS resolved
- All 5 stabilized, 3 at home
* Need an RCT
https://jamanetwork.com/journals/jama/fullarticle/2763983?utm_source=twitter&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=032720#.Xn5LBtcTflo.twitter
badseedboy
(174 posts)is huge!
FarPoint
(12,359 posts)I don't see it being readily available...it makes sense to do this....just saying...money is the determining end all factor.
totodeinhere
(13,058 posts)don't know if they are rich or not.
ck4829
(35,074 posts)For those who don't know; how you produce blood plasma is not a complicated procedure, you get blood, you run it through a centrifuge, you draw the yellow liquid in the separated mixture... blood plasma acquired.
Heck, you could get blood plasma yourself if you have 250 dollars lying around.
https://www.pulmolab.com/product_info.php/scientific-fixed-centrifuge-place-with-timer-p-222?gclid=EAIaIQobChMIrrqmhZW96AIVWf_jBx0w7QiPEAkYAiABEgIaVvD_BwE
We're going to watch another AZT, epi-pen, or daraprim situation unfold.
Hortensis
(58,785 posts)and this is GOOD news. Be glad. Anyway, one of the qualifying criteria was impending death. You don't want to qualify.
On to trials.
Link to tweet
BComplex
(8,050 posts)n/t
FarPoint
(12,359 posts)There are thousands of Plasma Centers that could collect the specimens...and process the end product with the needed IgG antibody.
But then...it is trump.....
Nah...it is so way over his head...beyond the scope of his comprehension...
Lochloosa
(16,064 posts)Maybe we should test them.
Wednesdays
(17,367 posts)Jirel
(2,018 posts)A sample size of 5 is not enough to tell us anything. Also, with no control group, there is no way to compare outcomes.
totodeinhere
(13,058 posts)octoberlib
(14,971 posts)drmeow
(5,017 posts)Single arm historical control trials are legit and are what I think we are going to have to rely on for this.
Wounded Bear
(58,653 posts)Promising news, though.
Hortensis
(58,785 posts)who already know a great deal about this century-old kind of treatment. At least we can reasonably assume there would be no shortage of antibodies to harvest from patients if needed.
Antibodies: In between these two approaches lies a method that has been used since the 1890s to treat various diseases the injection of virus antibodies into the bodies of patients or healthy individuals. In other words, unlike vaccines where the immune system generates antibodies to fight the virus, we can develop or harvest anti-bodies and inject them into patients and healthy individuals. Unlike vaccines, the period during which the antibodies will be effective is shorter (weeks to months), but these antibodies can be developed in a much shorter time than vaccines and can save lives until a vaccine is available.
There are two different approaches to developing antibodies one is to develop them based on knowledge of the SARS-CoV-2 virus structure and to grow them in lab animals; the other approach is to harvest antibodies from recovered Coronavirus patients. The 2nd approach is also known as plasma therapy, convalescent serum treatment and passive antibody therapy .
Plasma or Convalescent Sera Treatment
Here is an article published more than a week ago that provides some background on plasma treatment for COVID-19.
Link to tweet
emmaverybo
(8,144 posts)Last edited Fri Mar 27, 2020, 07:12 PM - Edit history (1)
How were the three at home on a ventilator?
Anyone able to translate this info into layperson terms?
Edited it. NOT RCT.
octoberlib
(14,971 posts)everything at patients in hopes that it would work and when it didnt tried plasma. Off of these results Mt Sinai is starting an RCT so would should get a better idea of how well this works.
emmaverybo
(8,144 posts)pat_k
(9,313 posts)uponit7771
(90,336 posts)Hortensis
(58,785 posts)needed. This DailyKos article from Mar 15 actually seems pretty informative and includes this treatment.
https://www.dailykos.com/stories/2020/3/15/1927475/-Some-Novel-Coronavirus-Treatments-in-the-Pipeline-Antibody-Harvesting-and-Plant-Based-Vaccines